6 ⅐ No. 1 review Attention deficit/hyperactivity disorder (ADHD): Complex phenotype, simple genotype? Maria Teresa Acosta,* MD1, 2, Mauricio Arcos-Burgos,* MD, PhD2, and Maximilian Muenke, MD2 Complex genetic traits refer to those phenotypes not fitting patterns of Mendelian segregation and/...
M., & International Working Group on Rodent Models of Narcolepsy. (2009). A consensus definition of cataplexy in mouse models of narcolepsy. Sleep, 32(1), 111–116. Article Google Scholar Chen, L., Brown, R. E., McKenna, J. T., & McCarley, R. W. (2009). Animal Models of ...
Nowhere is a definition of ‘molecular complementarity’ given in the text: there are many types of non-covalent interactions that hold things together in biological systems. A strategy of grouping all of them under the same term does not seem very helpful. If possible, provide a better example...
In reality, then, researchers must adjudicate both clinical significance and reporting obligations simultaneously in contexts that, by definition, involve scientific uncertainty. Beyond confirming the importance of clinical significance as a decision-making criterion in principle, our findings provide insight ...
Nowhere is a definition of ‘molecular complementarity’ given in the text: there are many types of non-covalent interactions that hold things together in biological systems. A strategy of grouping all of them under the same term does not seem very helpful. ...
(CDSs), they can result in the phenotype modification [8,16–18], even lead to the generation of toxic or malfunctioning proteins [19]. For example, the expansion of the (GAG)nmotif in the coding region of the Huntington’s disease (HD) gene in humans can lead to Huntington’s ...
Hybrid models are often multi-scale by definition, integrating processes on different temporal and spatial scales, such as gene expression, intracellular pathways, intercellular signaling, and cell growth or migration. There are two general classes of hybrid models, those that are defined upon a ...
Here, we are going to hypothesize that UMAP / tSNE components are linked to aphenotype of interest, that is MNISTlabelsin our case, or cell types for scRNAseq,rather than total variation in the data. To check this hypothesis, let us first explore how leading PCA, UMAP and tSNE components...
Cases 10 and 25 had a typical Burkitt lymphoma immuno- phenotype and case 24 expressed bcl-2 and had a Ki-67 of 90%. All three cases classified as diffuse large B-cell lymphoma had proliferation of large lymphoid cells with greater nuclear pleomorphism and prominent nucleoli (Figure 3c) ...
Definition Macroscopically visible cystic lesion of the pancreas without connection to the pancreatic duct system, lined by non-papillary mucinous epithelium, lackingovarian-likestroma, and usually lacking high-grade dysplasia. Clinical Features Incidence ...