In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity. General rules have been deduced for the design of new RNA enzymes capable of highly specific RNA cleavage, and have bee...
Hybrid models are often multi-scale by definition, integrating processes on different temporal and spatial scales, such as gene expression, intracellular pathways, intercellular signaling, and cell growth or migration. There are two general classes of hybrid models, those that are defined upon a ...
The idea of dominance refers to a type of inheritance, where one allele masks or hides the expression of another allele. Alleles are forms of a gene that have a particular trait. Gregor Mendel did early work in genetics, and he discovered this idea of dominance. He was working with pea ...
frequently than they were in the past.70,71 Caution must be used when comparing epidemiological data from different studies, because diverse types of instru- ments and questionnaires have been used in different epidemi- ological trials and the DSM-IV definition of impairment is operationally vague....
It has been proposed that the transcription of protein-coding genes occurs in nucleoplasmic hot spots (that is, transcription factories) where a high local concentration of the required molecular machinery renders the whole process more efficient [14, 15]. By definition, these harbour at least ...
In cells harboring this allele integrated into the chromosome, oriR6Kγ plasmids are maintained at a copy number of about 250 per cell which compares to 15 copies per cell when the pir+ allele is integrated at the same chromosomal locus [9]. The host range for oriR6Kγ-containing plasmids ...
The definition of F-statistics used here is [Math Processing Error]FST≡Q2-Q31-Q3, Where the Q are probabilities of identity in state, Q2 among genes in different individuals within groups (populations), and Q3 among groups (populations).The model-based program STRUCTURE 2.34 [69, 70] was...
The definition of the concentration of pheomelanin in the skin is an issue of great interest because in the case of being influenced by UV radiation, it manifests itself as a prooxidant, causing various skin disorders including melanoma that might help to explain the relatively high incidence of...
Distinguishing Burkitt lym- phoma from these morphological mimics remains a challenge, which is at least partially related to the sub- jective evaluation of cytomorphological features3,4,21 and the evolving definition of these lymphomas in light of recent gene-expression profiling studies.13,14 The ...
This indicates that the size of the region we defined for accepting significant SNPs in the cross-validation procedure was too large for the 800 K assay and highlights the difficulties that exist as to the definition of this region. The variation of the power of the CLIP test with residual...