For a number of reasons, polycythemia vera can cause your spleen to grow and become bigger. An enlargement of the spleen is known as splenomegaly (splee-nuh-MEG-uh-lee). Symptoms of an enlarged spleen can include: Pain or discomfort in your abdomen or under your left ribs Feeling full ...
MF patients suffered more frequently from constitutional symptoms of prominent fatigue and night sweats related to pronounced splenomegaly. Before the diagnosis was made in 497 MPN patients, the complaints were ascribed to other causes in 173 (35%): to stress, burned out or overstrained in 41 (...
We describe in detail the case of a male infant of a prostitute and IV drug abuser. The child presented at 9 mo of age with severely delayed growth (6.6 kg) and development, recurrent bacterial infections, lymphadenopathy, hepatosplenomegaly (8 cm), persistent oral candidiasis, and chronic ...
Another characteristic feature is the presence in the bone marrow of peculiar large cells with a foamy cytoplasm, the so-called Gaucher cells. In the infantile form of Gauchers disease, neurological symptoms dominate the clinical picture. The affected infant appears normal for the first few months...
Ruxolitinib, a JAK1/2 inhibitor approved for patients with primary and secondary MF, is effective in improving splenomegaly and disease-related symptoms. The agent “has little impact on bone marrow fibrosis, and a number of patients are refractory or develop secondary resistance,” noted investigato...
Common symptoms and signs included: change in bowel habits, gross or occult blood per rectum, involuntary weight loss, abdominal pain, abdominal tenderness, peripheral lymphadenopathy, cachexia, and hepatosplenomegaly. Significant gastrointestinal complications during the presenting admission included ...
Signs and symptoms of sarcoidosis vary widely depending on the organs affected. While many people who have sarcoidosis have very few or no signs of the disease, others suffer debilitating effects that can interfere with daily life. It is important to discuss all symptoms with your physician so ...
Penetrance of 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Only one of the 152 homozygotes had signs and symptoms that would suggest a diagnosis of haemochromatosis. Interpretation: The normal age distribution of ... Beutler,Ernest,Felitti,... - 《Lancet》 被引量:...
Cirrhosis is a complication of liver disease that involves the loss of liver cells. Learn about causes, treatment, symptoms, stages, life expectancy, and more.