The normal range for free lambda chains in serum was found to be 0.4–4.2 mg/1 and for free kappa chains it was 1.6–15.2 mg/1. At diagnosis the serum of most patients with multiple myeloma contained increased levels of the malignant free light chain and in some cases there was also ...
free light chainskappa/lambda ratioAs a heterogeneous group of diseases, monoclonal gammopathy is typical for older age and is characterized by the presence of paraprotein in serum and urine. In addition to damage to the bone marrow, other organs are also affected, whereas in the case of ...
Clinical Significance of Clonal Rearrangement of the Immunoglobulin Gene in the Bone Marrow of Patients with B-cell Non-Hodgkin Lymphoma METHODS: Forty two B-cell NHL patients were analyzed. Clonal rearrangements of the IG heavy chain (IGH), kappa light chain (IGK) and lambda light chain (IGL...
Development of a highly-sensitive multi-plex assay using monoclonal antibodies for the simultaneous measurement of kappa and lambda immunoglobulin free light chains in serum and urine J Immunol Methods, 391 (2013), pp. 1-13 Google Scholar 50. T. Nakano, A. Nagata ELISAs for free human immunog...
Katzmann JA, Clark RJ, Abraham RS, et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002;48(9):1437–44. ...
Additionally, free light chains (FLC) were measured in all samples. Definition of MGUS included M-protein concentration, laboratory results, and disease history. LCMGUS was defined as abnormal FLC ratio, increase in FLC causing the abnormal ratio, and lack of intact immunoglobulin. One hundred ...
light chains kappa and lambda (Thermo Fisher Scientific PN: 084910 and 083310), Life Technologies, Carlsbad, CA USA. After enrichment, samples were eluted with 20 μl of 5% acetic acid containing 50 mM tris [2-carboxyethyl] phosphine, to disassociate immunoglobulins into separated light-...
Abnormally higher levels of serum free light chains and abnormal kappa to lambda ratios are found in the majority of cases. The severity of disease correlates with the elevation and abnormal ratio of these free light chains. These values and ratios are widely used to determine the prognosis and...
Using assays for monoclonal (M)-proteins (electrophoresis/immunofixation) and kappa-lambda free light chains (FLCs), we determined longitudinally the prevalence of MGUS and characterized patterns of monoclonal immunoglobulin abnormalities prior to MM diagnosis. MGUS was present in 100.0% (87.2%-100.0%...
The mean value of monoclonal protein was 5,5 卤 4,8 g/L with 62,5% of the patients having an abnormal serum free light chain ratio. Table 1 describes the type of gammopathy found, being the IgG/Kappa the most observed. The immunoglobulin light chain amyloidosis (AL amyloidosis) and the...