Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS). Our aims were: (1) to compare the efficiency of KFLC through different interpretation approaches in diagnosing MS. (2) to ev...
Kappa free light chain (KFLC) index, a measure for intrathecal production of free kappa chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis (MS) as a quantitative alternative to IgG oligoclonal bands (OCBs). Our objective was to investigate the sensitivity,...
Primary systemic amyloidosis (immunoglobulin light chain-derived) (AL) is an uncommon dysproteinemia with highly varied initial clinical manifestations. Am... MA Gertz,RA Kyle - 《Mayo Clinic Proceedings》 被引量: 400发表: 1989年 Estimation of free light chains of immunoglobulins by enzyme immunoas...
A dynamic interpretation of κFLC index for the diagnosis of multiple sclerosis: a change of perspective Article Open access 28 August 2023 Cerebrospinal fluid kappa free light chains as biomarker in multiple sclerosis—from diagnosis to prediction of disease activity Article Open access 08 Februar...
Universal reference range independent of renal impairment simplifies result interpretation. Correlation of the FLC kappa/lambda ratio produced by N Latex FLC assay is accurate for samples at both high- and low-end concentrations vs. the ratio produced by the FREELITE assay, which can be severely ...
(www.idtdna.com) and subsequently cloned into IgG and IgK expression vectors as previously described56. Equal ratios of heavy- and light-chain plasmids were co-transfected into 293F cells using FreeStyle MAX (Invitrogen) according to the manufacturer’s instructions. Protein G columns were used ...
the presence of a monoclonal immunoglobulinor a free monoclon- al light chain (Bence Jones Protein) in the urine caus- es a shift in the xA ratio. Immunonephelometrical analysis of xA ratio in the urine is a much simpler and quicker method than the common immunoelectrophoresis (IEP) and ...
the presenceof a monoclonal immunoglobulin or a free monoclon-al light chain (Bence Jones Protein) in the urine caus-es a shift in the xA ratio.Immunonephelometrical analysis of xA ratio in theurine is a much simpler and quicker method than thecommon immunoelectrophoresis (IEP) and im-munofi...
Fig. 1: Patient profiles of percent change in serum κ free light chain (κFLC) concentrations from baseline after MDX-1097 intravenous infusion, presented by dose cohort. Cohort 1 (0.3 mg/kg;a,e), Cohort 2 (1.0 mg/kg;b,f), Cohort 3 (3.0 mg/kg;c,g), and Cohort 4 (...
Kappa free light chains in cerebrospinal fluid as markers of intrathecal immunoglobulin synthesis. Clin. Chem. 2004, 50, 1809–1813. [Google Scholar] [CrossRef] [PubMed] Kaplan, B.; Aizenbud, B.M.; Golderman, S.; Yaskariev, R.; Sela, B.A. Free light chain monomers in the ...