Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked to tumor invasion or metastasis, and therapeutic resistance in various human cancer. A growing body of recent evidence has supported the hypothesis t
Results: We observed c-MYC gain in 20% (51 out of 255), chromosome 8 gain in 5.5% (14 out of 255), c-MYC amplification in 2.4% (6 out of 255), EGFR mutation in 49.4% (118 out of 239), KRAS mutation in 5.7% (7 out of 123), and ALK rearrangement in 4.9% (10 out of ...
Differences between Kaplan–Meier survival curves were calculated by the log-rank test. Results The number of different glioma samples evaluated for the molecular markers is shown in Table 1. Overall, complete 1p/19q co-deletion was detected in 34% of low-grade gliomas, in 52% of anaplastic ...
Methylation of theMGMTpromoter in the CpG-rich region results in epigenetic silencing (decreased expression) of theMGMTprotein.MGMTpromoter methylation is seen in approximately 40% of all GBMs [8] and can be measured through various methodologies, such as methylation microarray or bisulfate sequencing...
The level of significance was set at P < 0.05. Results Clinical presentation This series of 92 cases included 42 male patients (45.7%) and 50 female patients (54.3%). The mean age at the time of histological diagnosis was 47.2 years (range: 2 to 84 years). Fifty eight patients (63.0%...
and TLR4. However, the best inferred functional partners found formiR192are as follows, in descending order: IL-6, TP53, INS, PPARG, STAT3, TLR4, VEGFA, BCL2, EGFR, ADIPQ, HIF1A, KRAS,miR21, IGF1, and PTEN. Interestingly, the best inferred functional partners found formiR199A1weremiR...
However, the best inferred functional partners found for miR192 are as follows, in descending order: IL-6, TP53, INS, PPARG, STAT3, TLR4, VEGFA, BCL2, EGFR, ADIPQ, HIF1A, KRAS, miR21, IGF1, and PTEN. Interestingly, the best inferred functional partners found for miR199A1 were miR...
test, and, for assessment of CPA4 mRNA, we used the PCR method. The serum CPA4 (p= 0.001) and CPA4 mRNA (p= 0.015) levels were found to be statistically significantly higher in the controls, compared to the patient group. When the results of patient group were statistically analyzed ...