Metabolome analysis including amino acid profile is under investigation as an approach in cancer screening. The present study aims to analyze plasma free amino acid (PFAA) profiles in cancer patients and investigate their potential as biomarkers of malig
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Currently MEME evaluates its EM-generated candidate motifs using an extension of BLAST’s E-value to the motif-finding context. Although we previously indicated the drawbacks of MEME’s current significance evaluation, we did not offer a practical substitute suited for its needs, especially because ...
eTable 2. Adverse events by timing of most recent heart failure hospitalization in relation to trial enrollment. 1. McMurray JJV, Solomon SD, Inzucchi SE, et al; DAPA-HF Trial Committees and Investigators. Dapagliflozin in patients with heart failure and reduced ejection fraction. ...
The explosion created a (literally) deafening blast of sound, and a wave of pressure so powerful that it could easily be detected by weather stations around the globe, both those of professionals and those in the homes of ordinary people. In fact, many stations detected the wave passage multi...
In patients with AML, the PB blast clearance rate (PBCR) is closely correlated with treatment response and survival, but sampling time point and cut-off value vary [12-16]. In this study, we assessed the prognostic value of PBCR during induction in a cohort of 96 newly diagnosed AML ...
of hybridization. Observed hybridization profiles are then compared to the theoretical profiles using a similarity metric, and apvalue calculated using a set of experimentally obtained null probability distributions. E-Predict has been shown to produce useful results in a number of situations. However,...
Methods to improve the predictive value of interim PET/CT include quantitative approaches, such as measuring the rate of reduction in maximum SUV (ΔSUVmax) or metabolic tumor volume (ΔMTV), defined as the volume of tumor tissue with increased FDG uptake. A quantitative approach might be more...
Microbial communities are major drivers of global elemental cycles in the oceans due to their high abundance and enormous taxonomic and functional diversity. Recent studies assessed microbial taxonomic and functional biogeography in global oceans but mic
The specific molecular mechanisms underlying this context dependence are almost entirely unknown, yet this must be addressed if we are to harness the potential therapeutic value of these powerful regulatory proteins. A number of matricellular proteins are currently involved in clinical trials (5, 47),...