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The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating many physiological processes in development and tissue homeostasis. The TGF-β signaling pathway outcome relies on the control of the spatial and temporal expression of >500 genes, which depend on the funct...
In the light of the crucial roles of both TGF-β and RAC1 in tumor growth and various stages of the metastatic process (Fig. 1), it was not unexpected that RAC1 can also transduce signals from other receptors, e.g. those for TGF-β which have serine/threonine kinase activity. We and...
Moustakas Signaling receptors for TGF-beta family members Cold Spring Harb. Perspect. Biol., 8 (2016), 10.1101/cshperspect.a022053 Google Scholar Hurley, 2015 J.H. Hurley ESCRTs are everywhere EMBO J., 34 (2015), pp. 2398-2407 CrossrefView in ScopusGoogle Scholar Husebye et al., 2006 ...
Hao Y, Baker D, Ten Dijke P (2019) TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis. Int J Mol Sci 20:2767 Article CAS PubMed PubMed Central Google Scholar Heldin CH, Moustakas A (2016) Signaling receptors for TGF-β family members. Cold Spring Harb Perspect Biol ...
The TGF-β family members signal via heteromeric complexes of type I and type II receptors, which activate members of the Smad family of signal transducers. The main attribute of the TGF-β signaling pathway is context-dependence. Depending on the concentration and type of ligand, ...
The TGF-β family members signal via heteromeric complexes of type I and type II receptors, which activate members of the Smad family of signal transducers. The main attribute of the TGF-β signaling pathway is context-dependence. Depending on the concentration and type of ligand, target tissue...
Transforming growth factor-β (TGF-β) is a pivotal cytokine that regulates the growth and differentiation of many different cell types. The TGF-β family signals via specific serine/threonine kinase receptors and intracellular signal-transducing molecules, termed Smads (Massagué et al., 2005). TG...
Members of the TGF-β family elicit their cellular effects by binding to a complex of type II and type I serine/threonine kinase transmembrane recep- tors (Figure 1). Five type II receptors and seven type I re- ceptors, also termed activin receptor-like kinases (ALKs) are present in ...