Therapeutic improvement is always derived from novel achievements in mechanistic or technical research. Therefore, to provide insights for future translational efforts, we believe it is important to review these achievements. In this paper, we reviewed signaling cascades involved in failing hearts and eme...
In this study, we investigate the in vivo activation of mitogen-activated protein kinases (MAPK) as important signal transduction cascades observed after m... T Omura,M Yoshiyama,T Shimada,... - 《Journal of Molecular & Cellular Cardiology》 被引量: 217发表: 1999年 Myocardial ischemia and rep...
Nevertheless, gp130 also activates other signal transduction cascades, including PI3k/Akt pathway401, as well as MAPKs (ERK1/2, JNK, p38, and ERK5)402,403,404. Of note, the differential activation of cell types and cytokines selectively activates many pathways with distinct relative activation ...
is activated through dimerization to trigger its intrinsic intracellular protein-tyrosine kinase activity, followed by activation of numerous down signaling cascades in cells.127The c-Cbl is a well-known ubiquitin E3 ligase to target EGFR for ubiquitylation, which serves as a sorting signal for...
European Journal of PharmacologyWitte K, Kinzler N, Schnecko A, Oldrich HG, Lemmer B. Effects of β-adrenoceptor blockade on β-adrenergic signal transduction in cardiomyopathic hamster (BIO 8262) hearts. Eur J Pharmacol. 1997;334:209-216....
pore (mPTP), non-specific channel assembled by a large protein complex that located in the IMM, is involved in the regulation of apoptosis. Opening the mPTP leads to the release of Cyt C and other apoptotic molecules from the mitochondria into cytoplasm, triggering the apoptotic cascades. ...
Recent investigations have shown that Ang II stimulates the generation of ROS by activating membrane-bound NAD(P)H oxidase in a variety of cells [11]. ROS may act as a second messenger and regulates various intracellular signal transduction cascades and the activity of various transcription factors...
6. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. [O] . D T Denhardt 1996 机译:Ras / Rho蛋白在哺乳动物细胞中介导的信号转导蛋白磷酸化级联反应:多重信号转导的潜力。 7. Poster session 2Morphogenetic ...
Neddylation in health: regulation of biochemical reactions and biological processes By targeting numerous cullin and non-cullin proteins, neddylation pathway is able to directly or indirectly regulate multiple signaling transduction pathways involved in a variety of biological processes, including cell cycle ...
The deleterious impacts of AGEs could be attributed to three primary molecular mechanisms: modification of extracellular proteins, alteration of intracellular proteins, and activation of signaling cascades by binding to the receptor for AGE (RAGE) situated on the cell surface. ...