In recent years, the biochemical events implicated with the signal transduction cascade responsible for transmission of signal from the cell surface to the nucleus have been studied in detail in a wide variety of cellular systems, including lymphocytes. It is now evident that multiple steps of the...
Genetic deletion of fumarase increased the intracellular concentration of fumarate and enhanced the switching frequency of the flagellar motors irrespective of the presence or absence of the phosphorylation cascade. These correlations provide evidence for fumarate-dependent metabolic signal transduction in ...
Such an analysis was utilized in order to study the signal transduction cascade activated by the binding of thymic stromal lymphopoietin to its cytokine receptor, as the ligand's overexpression has been linked to the development of asthma in patients. A quantitative phosphoproteomic approach was used...
currently known to be mediated by a phosphorylation/dephosphorylation ("phosphorelay") cascade that alters the stability of two master transcription regulators... Y Zhao,Z Qi,GA Berkowitz - 《Plant Physiology》 被引量: 50发表: 2013年 Phytochrome-mediated signal transduction pathways in plants Phytochr...
Signal transduction The signalling cascade is essential in the pathogeny because it links the fungal response with the changes in the surrounding environment. Qualitative analyses of proteins identified in each assayed condition suggested possible alterations in five of the most important signalling networks...
Model of the regulatory signalling cascade that controls SigB activity. The model highlights the role of RsbV phosphorylation in controlling SigB activity, through its modulation of the levels of free RsbW, the anti-sigma factor that sequesters SigB. RsbT is released from the stressosome follow...
Additional experiments, guided by kinetic modeling, show that this slow process is consistent with ERK's modification of and release from nuclear substrates.Keywords -- signal transduction, MAPK cascade, kinetic modeling, receptor tyrosine kinase. 展开 ...
The PLA signal was quantified (n > 300). (L) A proposed model of the HTATSF1-TOPBP1 complex nucleated PARylation and phosphorylation cascade in TOPBP1 loading and RPA-RAD51 exchange. Scale bars, 10 μm. Data are mean ± SD. ∗∗p < 0.01; NS, not significant. See also Figure ...
Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors. In the Drosophila visual cascade, the transient receptor potential (TRP) calcium channel, phospholipase Cbeta (no-receptor-potential A), and an eye-specifi... M Liu,LL Parker,BE Wadzinski,... - 《Journal ...
Here we provide evidence for a direct involvement of DPIV/CD26 in early phosphorylation mechanisms which are known to be essential in the signal transduction cascade of human T lymphocytes. We have found that DPIV-specific inhibitors (Lys[Z(NO2)]-thiazolidide and -piperidide) are capable of...