However, Siglec-H expression was absent from CNS-associated macrophages and CNS-infiltrating monocytes, except for a minor subset of cells. We also show that the Siglech gene locus is a feasible site for specific targeting of microglia in the nervous system. In conclusion, Siglec-H is a ...
Here, we performed in silico analysis of the function of three major protective alleles in the locus and found that these alleles were expression quantitative trait loci that enhanced expression of the adjacent SIGLEC12 gene. These data suggest that SIGLEC12 may protect against the development of ...
Entrez Gene IDs 233274 (Mouse) Alternate Names 6430529G09Rik; Siglech sialic acid binding Ig-like lectin H; SiglecH; Siglec-H Related Research Areas Dendritic Cell Activation Dendritic Cell ITIM/ITAM Immunoreceptors Ig-type Lectins ITIM/ITAM Immunoreceptors and Related Molecules...
蛋白别名: sialic acid binding Ig-like lectin H; Siglec; SIGLEC-like protein 基因别名: 6430529G09Rik; Siglec-H Entrez Gene ID: (Mouse) 233274 功能 sialic acid binding cargo receptor activity immunoglobulin superfamily cell adhesion molecule 参与通路 receptor-mediated endocytosis 性能保障 只要...
Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" that modulate innate immunity via engagement of CD33-related-Siglec receptors....
These mice carry loxP sites flanking target exons 5-11 of Siglecg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Siglecg gene. *使用本品系发表的文献需注明: Siglecg-Flox mice (Cat. NO. NM-CKO-2116054...
Primer sequences to detect the SIGLEC-6 gene are as follows: Forward primer 5′-TTTGTGCATTGGAAACCAGA-3′ and reverse primer 5′-CTGTCTGGAACTGGTGCTGA-3′. Humanized CD3ε mice were kindly provided by Dr. Meixiao Long (The Ohio State University). To generate them, human CD3 transgenic ...
et al. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin- mediated but not E-selectin-mediated neutrophil rolling and migration. J Exp Med 190, 1769–1782 (1999). 7. Lock, K., Zhang, J., Lu, J., Lee, S. H. & Crocker...
上海玉博生物科技有限公司 主要致力于“anti-mouse siglec H PE (Clone: eBio440c) 100 ug eBioscience-12-0333-82”的生产销售。多年的“anti-mouse siglec H PE (Clone: eBio440c) 100 ug eBioscience-12-0333-82”生产与销售的经验,与各行业新老用户建立了稳定的合作关
in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens. Long Name: Sialic Acid Binding Ig-like Lectin 5 Entrez Gene IDs: 8778 (Human) Alternate Names: CD170;CD33L2;OBBP2;OB-BP2;Sialic acid-binding Ig-like lectin 5;SIGLEC5;SIGLEC-5; Siglec-5/Siglec...