The pathological process encompasses inadequate oxygen delivery to brain tissue, as well as damage and dysfunction of mitochondria. Additionally, oxidative phosphorylation, the tricarboxylic acid (TCA) cycle, and the electron transport chain face inhibition, significantly reducing ATP synthesis and impairing...
extrinsicpolypeptidetrichloroacetate(TCA-NaOH)FTIREPRsignalⅡ.PHOTOSYSTEM Ⅱ (PS Ⅱ) particles capable of O2 evolution contain reaction center polypeptides D1 and D2, cytchrome b559, chlorophyll (Chl)-binding proteins CP47 and CP43, three extrinsic polypeptides (with apparent molecular masses of 17...
Yes, weight gain has been reported as a common side effect with amitriptyline and may occur in 1% to 10% of patients. Amitriptyline is a tricyclic antidepressant (TCA) and other drugs in this class have been associated with weight gain. TCAs block histamine receptors which may be responsible ...
Combining tricyclic antidepressants (TCAs) with clonidine (Catapres) may lead to dangerous elevations in blood pressure because TCA may inhibit the antihypertensive effect of clonidine. Combining TCAs with carbamazepine (Tegretol) may result in lower TCA blood levels and higher carbamazepine levels, leadi...
Serotonin syndrome is a serious side effect and may be fatal. Symptoms include fever, muscle stiffness, and changes in mental status such as confusion or hallucinations. The risk of neuroleptic malignant syndrome (restlessness, sweating, fever, confusion, and muscle stiffness) may increase with ...
In male rats, oral administration of DMF (75, 250, and 375 mg/kg/day) prior to and throughout the mating period had no effect on fertility; however, increases in non-motile sperm were observed at the mid and high doses. The no-effect dose for adverse effects on sperm is similar to...
drugsthat slow the brain's function, such asalcohol,barbiturates,benzodiazepines, for example,lorazepam(Ativan),diazepam(Valium),temazepam(Restoril),oxazepam(Serax),clonazepam(Klonopin) as well aszolpidem(Ambien) and narcotics. Reserpine has a stimulatory effect on patients taking TCAs. ...
The patient with may exhibit suicidal tendencies; thus, overdose of a prescribed TCA may occur, resulting in a potentially . The cardiotoxic effect of TCA overdose is the most pronounced complication. Multiple rhythm disturbances may occur in the presence of a TCA overdose. The greatest number ...
Shortness of breath Muscle pain Rash There may be other side effects of Zelapar that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by ca...
Shortness of breath Muscle pain Rash There may be other side effects of Zelapar that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA atwww.fda.gov/medwatchor by callin...