Sickle cell disease is a common and life-threatening haematological disorder that affects millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in small vessels, and this vaso-occlusion leads to distal tissue ischaemia and inflammation, with symptoms defining the acute ...
Sickle cell disease is a genetic condition that people are born with, so there isn't a way to prevent it. By law, all babies born in the U.S. are screened for sickle cell at birth. A child must inherit a sickle cell gene from both parents to develop the disease. Genetic testing al...
Sickle Cell Disease ImportanceSickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and increased mortality. An es...
Sickle cell disease is an autosomal recessive blood disorder that can lead to anaemia. It is caused by a mutation in the haemoglobin gene, which leads to deformation of red blood cells. Deformed red blood cells can obstruct small vessels and they are prone to destruction. ...
Visit the site to learn about sickle cell, a genetic disease. View patient stories, learn about the diagnosis, disease management, support resources, and more.
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Ha
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Haemoglobin molecules that include mutant ...
Sickle Cell Disease (Clinical) Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous...
You may need to take certain vitamins and have 1 or more blood transfusions during pregnancy. You will pass a gene for sickle cell disease to your child. Your partner should be tested for the sickle cell gene. This information can help predict your child's risk for sickle cell disease....
1. Disease Overview Key biologic and clinical features of sickle cell disease that impact patient outcomes Switching from fetal to adult hemoglobin The protective role of HbF in sickle cell disease Impact of abnormal RBCs on disease pathophysiology ...