Sickle cell diseaseSickle cell disease is a fatal systemic condition characterized by acute painful episodes, persistent anemia, ongoing organ damage, organ infarction, and a markedly shorter average lifetime. It first appeared in the tropics' malarial zones, where carriers benefit from an evolutionary...
Patients with sickle-cell haemoglobinopathy are more susceptible to osteomyelitis than normal people. The commonest causative organism in such cases has be
Factors Influencing Adherence to Hydroxyurea Treatment Among Children with Sickle Cell Disease at the Mother and Child Center of the Chantal Biya Foundation PDF | Full-text Ndoumba Mintya AnnickFactors Associated with Junk Food Consumption Affecting Saudi University Female Students PDF | Full-text ...
All Recent ArticlesHigh Vaccine Hesitancy during the COVID-19 Emergency Campaign on the Tourist Island of Marajó, Amazon Region of Brazil Leonardo Miranda dos Santos Journal of Infectious Diseases and Pathogenesis Introduction: Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory ...
Sickle cell disease tracrRNA: Trans-activating CRISPR RNA TAM: Transposon-associated motif TDT: Transfusion-dependent beta thalassemia UGI: Uracil-DNA glycosylase inhibitor UNG: Uracil-DNA glycosylase VLP: Virus-like particle References Doudna JA, Charpentier E. Genome editing. The new frontier of genom...
genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administer- ing an agent that modulates MBD protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. The...
including cell proliferation, differentiation, migration, disease occurrence, and progression.99There has been extensive research on the regulatory mechanisms of miRNAs. With the assistance of complexes, such as Drosha/DGCR, Exportin-5/RAN-GTP, and Dicer/TRBP, primary miRNAs (pri-miRNAs) transcribed...
The advent of gene editing technology that relies on electroporation technology for protein delivery has facilitated the approval of the first gene editing therapeutic drug, Casgevy, which can be used to treat transfusion-dependent beta-thalassemia (TDT) and sickle cell disease (SCD) [7, 8]. Nev...
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ... DOI :10.12659/MSM.944204 Med Sci Monit 2024; 30:e944204 0:00 28 Jan 2024 :Review article17,894 A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future...
Fig. 1: A schematic overview of genome engineering strategies for the functional study of disease-associated genetic variants. CRISPR‒Cas toolkits are classified into three categories on the basis of the use of nucleases, base editors, and prime editors. Red arrows indicate DNA breaks induced by...