Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous condition, is the only 1 of...
Sickle cell disease is an inherited disease that affects the shape of the red blood cells. The disease causes the red blood cell to adapt a sickle like shape. This can cause issues because it does not flow through the body's vessels th...
As an inherited disorder commonly found in individuals of African descent, sickle cell anemia affects red blood cells, making them abnormally sickle-shaped, which results in a blockage of blood flow. Learn more about sickle cell anemia, including the affect...
As an inherited disorder commonly found in individuals of African descent, sickle cell anemia affects red blood cells, making them abnormally sickle-shaped, which results in a blockage of blood flow. Learn more about sickle cell anemia, including the affected locations of the body and the signs,...
Gaston4, Kwaku Ohene‑Frempong5, Lakshmanan Krishnamurti6, Wally R. Smith7, Julie A. Panepinto8, David J. Weatherall9, Fernando F. Costa10 and Elliott P. Vichinsky11 Abstract | Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB...
Sickle cell disease affects approximately 0.2% of African Americans. The prevalence of sickle cell disease in non-African Americans is approximately 0.08% [2]. 1.1.7 In Saudi Arabia In the Eastern Province, 20–30% of Saudi newborns are heterozygous for the sickle gene and 1.6–2.3% may be...
Sickle cell disease or sickle cell anemia is the most common of the hereditary blood disorders among black people of African descent worldwide. Learn about symptoms, treatment, causes, inheritance, testing, complications, and more.
Sickle-cell disease affects 8 million people globally4, particularly in resource-limited regions where the intricacies of transplants may pose a barrier to treatment. So, the need to ensure the accessibility of novel treatments is paramount. The emerging focus on disease-modifying therapies (DMTs),...
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Ha
2) What are the key feasibility findings? The key feasibility findings of this work are that the Sickle Cell Disease Functional Assessment (SCD-FA) is feasible, acceptable, and safe with 80% of approached patients consenting to participate, 91% completing the SCD-FA, and nearly all participants...