Acute sickle cell hepatic crisis (ASCHC) if the obstruction is not extensive Sickle cell intrahepatic cholestasis (SCIC): a severe, often fatal variant of ASCHC that occurs if the obstruction is extensive; associated with severe jaundice and renal impairment Both ASCHC and SCIC are associated wit...
Sickle cell crisis, a hallmark of sickle cell anemia, arises from the unique pathophysiology of this inherited hemoglobinopathy. The condition, characterized by a point mutation in the beta chain of the globin gene, leads to the synthesis of abnormal HbS protein, causing various crises. Vaso-occlu...
Sickle Cell Disease Sickle cell disease complications during pregnancy include sickle cell crisis affecting the bones and joints which can occur at any time during pregnancy, labour and the puerperium. Crises during the last 4 weeks of pregnancy and the first 4 days after delivery are more severe...
Sickle cell disease (SCD) encompasses a group of disorders characterized by the formation of sickled red cells, chronic hemolytic anemia, and episodes of vaso-occlusion. The condition is due to the presence of ...
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), a
SCD may also cause low red blood cell (RBC) levels (anemia).Common symptoms include the following:The following symptoms may come and go, or may happen during a sickle cell crisis:Low energy Pain anywhere in your body Pale skin Headaches Shortness of breath...
Sometimes a red blood cell exchange is performed. This process removes some of the sickle blood cells and replaces them with normal (non-sickle) blood cells. It is done when the sickle cell crisis is so severe that other forms of treatment are not helping. Pain crises Pain crises in ...
For columnist Mary Shaniqua, one of the hardest aspects of sickle cell is its unpredictability, such as the sudden onset of a pain crisis. Read the column Your sickle cell community Visit theSickle Cell Disease Newsforums to connect with others in the sickle cell community. ...
When this happens, it is called a sickle cell crisis. SCD also causes RBCs break apart and die faster than healthy RBCs. This causes low red blood cell levels (anemia).What causes SCD?SCD is passed from parents to a child. A child is given 2 abnormal genes for hemoglobin, 1 from ...
Pain due to sickle cell crisis—the most common symptoms of sickle cell disease are episodes of pain that can last for extended periods of time. The pain can occur throughout the body and often involves the bones, joints, lungs, and stomach. ...