Sickle Cell Disease (Clinical) Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous...
Children with sickle cell disease (SCD) have varied clinical problems. The hallmark manifestation of SCD, the pain crisis, typically first occurs in early childhood presenting as dactylitis. Pain increases in frequency and severity as children age, especially during adolescence. Due to functional ...
Clinical manifestations includ- ing the "sickle crisis." Arch Intern Med 1974;133(4):611-9.Konotey-Ahulu FI. The sickle cell diseases. Clinical manifestations including the "sickle crisis." Arch Intern Med... FI Konotey-Ahulu - 《Archives of Internal Medicine》 被引量: 199发表: 1974年 ...
The sickle cell diseases are disorders in which ‘sickling’ of erythrocytes produces clinical manifestations. In 1910, James Herrick was the first to observe sickled cells and, in 1923, it was demonstrated that the sickling phenomenon was inherited as an autosomal dominant trait. Subsequently, the...
12 The actual risk of stroke may be significantly higher, however, because up to 24 percent of patients with HbSS have silent infarcts on neuroimaging, with no apparent clinical manifestations.76 Most strokes in patients with sickle cell disease are ischemic, although older individuals are also at...
The Sickle Cell Diseases: Clinical Manifestations Including the "Sickle Crisis." Arch Intern Med. 1974; 133(4):611-619. 3. World health Assembly. Sickle-Cell Anaemia: Report by the Secretariat. 2006. Available at: http:/ /apps.who.int/gb/ebwha/pdf_files/WHA59/ A59_...
Clinical Manifestations of SCD - anemia (5 -11 g/dL) - jaundice (Sickle cells do not live as long as normal red blood cells and, therefore, they are dying faster than the liver can filter them out. Bilirubin (which causes the yellow color) from these broken down cells builds up in th...
The treatment of sickle cell disease requires familiarity with the medical manifestations of the vaso-occlusive and hematologic crises and their complications. This discussion deals with treatment of the sickle cell crises and major clinical manifestations of the disease. At present, treatment is primaril...
Clinical manifestations and course of sickle-cell anemia are variable. Knowledge about the factors, possibly geographic, that influence prognosis are still scanty. Data of hospitalization and management of children with sickle-cell disease were studied during two years (1992-1993) in the Pediatric Unit...
Two individual cases in which mental nerve paresthesia developed concurrently with sickle-cell crisis are described. A brief review of the hemoglobinopathies follows, with genetic considerations and clinical manifestations discussed.Access through your organization Check access to the full text by signing...