Sickle Cell Disease (Clinical) Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous...
Clinical manifestations includ- ing the "sickle crisis." Arch Intern Med 1974;133(4):611-9.Konotey-Ahulu FI. The sickle cell diseases. Clinical manifestations including the "sickle crisis." Arch Intern Med... FI Konotey-Ahulu - 《Archives of Internal Medicine》 被引量: 199发表: 1974年 ...
The sickle cell diseases are disorders in which ‘sickling’ of erythrocytes produces clinical manifestations. In 1910, James Herrick was the first to observe sickled cells and, in 1923, it was demonstrated that the sickling phenomenon was inherited as an autosomal dominant trait. Subsequently, the...
sickle‐cell diseaseutilizationBackgroundAcute and chronic clinical manifestations of sickle-cell disease (SCD) lead to significant healthcare utilization, especially of the emergency department (ED). Limited population-level data are available in SCD with the ability to connect patients to visits, ...
(HbS,α2βS2). At low oxygen tension, HbS forms rigid polymers that cause characteristic red blood cell (RBC) shape changes and initiate a complex pathophysiology that includes haemolysis, microvascular occlusions and inflammation. Clinical manifestations include anaemia, immunodeficiency, multi-organ ...
(redirected fromsickle cell–thalassemia) Dictionary Thesaurus Medical Related to sickle cell–thalassemia:sickle cell thalassemia disease [‚thal·ə′sē·mē·ə] (medicine) Ahereditaryformofhemolyticanemiaresultingfromadefectivesynthesisofhemoglobin:thalassemiamajoristhehomozygousstateaccompaniedbyclinicalilln...
c.55L > M polymorphisms on PON1 activity and laboratory parameters and the association between PON1 activity and clinical manifestations in SCD patients. We recruited 350 individuals, including 154 SCD patients and 196 healthy volunteers, which comprised the control group. Laboratory parameters ...
To the editor: Does increased red blood cell deformability raise the risk for osteonecrosis in sickle cell anemia? 9. Nouraie M, Lee JS, Zhang Y, et al. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with si... McGeechan,Macas...
Sickle cell disease (SCD) is an inherited abnormality of the -globin chain, which causes a spectrum of haemolytic anaemias. Clinical manifestations in SCD include anaemia, jaundice, recurrent vaso-occlusive crises, and infections (particularly by encapsulated bacteria) due to functional asplenia and ...
Introduction: Sickle cell disease is an inherited chronic haemolytic anaemia. Its clinical manifestations are due to the tendency of the haemoglobin to polymerize and red blood cells to deform into the characteristic sickle shape. Trace ... A Ahmed 被引量: 0发表: 2011年 TOTAL HIP ARTHROPLASTY AS...