The molecular docking study showed the affinities of compounds 5c and 5d toward STAT1 protein and compound 5i toward KRAS with promising energy scores. The subsequent molecular experiments were studied on compounds 5b, 5c, 5d, 5f, and 5i. Quantitative Real-time-PCR revealed that the expression ...
遗传 性免疫缺陷综合征(如慢性肉芽肿病和STAT1(功/)能获得性疾病)患者反而会因暴发性感染出现细 胞因子风暴78 (http://#78). 特发性多中心卡斯尔曼病是与HHV-8相关多中心卡斯尔曼病类似的另外一种细胞因子风暴, 但病因未知.血小板减少,全身水肿,发热,网状纤维化和器官肥大(TAFRO)亚型的患者往往 细胞因子风暴最...
pnas.201408759SI Lin et al.10.1073/pnas.1408759111 Fig.S1.Safety and potential toxicity evaluation of M1in immunocompetent mice.Immunocompetent BALB/c mice received two doses of i.v.infusion of either M1(3×107pfu per dose)or vehicle.(A)Body weight was measured every3d.Means±SDs are ...
We demonstrate that in response to IL-31, its receptor complex recruits Jak1, Jak2, STAT1, -3, -5 signaling pathways, as well as the Pi3 kinase / AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in ...
RELA, VEGFA, and STAT1 were the important target genes in the gene network associated with the THSWT formula for the treatment of ONFH. Therefore, the present study suggested that the THSWT formula has an action mechanism involving multiple compounds and network targets for the treatment of ...
Yupingfeng powder could decrease expression of JAK1, STAT1, STAT4, SOCS4_ predicted, Epidermal growth factor receptor (EGFR), PRLR, High mobility group AT-hook 1 (HMGA10), IL-4. Conclusion Sijunzi decoction and Yupingfeng powder can improve immune function of the rat through influencing the...
"1024" "Stat1" "1025" "Stat2" "1026" "Stat3" "1027" "Stat4" "1028" "Stat5a" "1029" "Stat5b" "1030" "Stat6" "1031" "Sub1" "1032" "T" "1033" "Tada2a" "1034" "Tada2b" "1035" "Tal1" "1036" "Tal2" "1037" "Tax1bp1" "1038" "Tbr1" "1039"...
Epigenetics is the study of changes in gene expression that modify DNA, RNA, and protein – but do not alter the primary sequence. The most common types of epigenetic modifications are methylation, acetylation, phosphorylation, and ubiquitination. These modifications lead to ste...
Taohong Siwu Decoction (THSWD) is a widely used traditional Chinese medicine (TCM) prescription in the treatment of ischemic stroke. There are thousands of chemical components in THSWD. However, the key functional components are still poorly understood. This study aimed to construct a mathematical...
哺乳动物STAT家族包括STAT1、STAT2、STAT3、STAT4、STAT5a、STAT5b和STAT6,它们介导多种细胞内信号通路。其中,STAT3参与了细胞的增殖、存活、分化和血管生成等多种生物学过程。在正常细…阅读全文 赞同66 3 条评论 分享收藏 赞同了回答2023-09-24 07:22 怎么知道自己是适合临床研究还是基础...