同时,CPDA/siSTAT3@SCM纳米粒子可以有效的将STAT3siRNA转染到骨肉瘤MG63,HOS细胞中,其转染效率优于目前脂质体转染试剂的转染效率.凋亡相关蛋白的结果显示CPDA/siSTAT3@SCM纳米粒子较其他组相比,具有显著的Bax,Bad,Cleaved-caspase3蛋白促进能力以及Bcl-2蛋白的抑制能力.最后,EMT相关蛋白结果证实CPDA/siSTAT3@SCM纳米粒子...
siSTAT3 inhibits HIV-1-infected MDM-induced NPC astrogliogenesis.Hui, PengLijun, SunBeibei, JiaXiqian, LanBing, ZhuYumei, WuJialin, Zheng
Conclusion: This study revealed that CPDA/siSTAT3@SCM NPs can target drug delivery by biomimetic multifunctional nanoparticles to treat OS through chemo-gene combined therapy.doi:10.1186/s12645-023-00215-5Wu, KunzheZhou, ZhongshengLiu, TeLiu, Chunkang...
Effect of siSTAT3 or curcumin on proliferation of NCI-H446 cells.ChengLiang, YangYongYu, LiuYeGang, MaYiXue, XueDeGui, LiuYi, RenXiaoBai, LiuYao, LiZhen, Li
METHODS: Plasmid pEndo-Si-Stat3 was constructed and introduced into an attenuated strain of Salmonella enterica serovar typhimurium. The resultant recombinan...Erika Caldwell
In the model, it was confirmed that the PLGA-siSTAT3 reduced the clinical symptom index induced by EAE and inhibited demyelination of the spinal cord. In addition, it was confirmed that it blocks the STAT3 signaling pathway related to EAE, reduces demyelination, and suppresses the expression of...
STAT3 signaling pathwayBenzothiazoleRational designAntitumor activityMolecular dockingThe cumulative evidence supports STAT3, a transcriptional mediator of oncogenic signaling, as a therapeutic target in cancer. The development of STAT3 inhibitors remain an active area of research as no inhibitors have yet to...
STAT3 signaling pathwayBenzothiazoleRational designAntitumor activityMolecular dockingThe cumulative evidence supports STAT3, a transcriptional mediator of oncogenic signaling, as a therapeutic target in cancer. The development of STAT3 inhibitors remain an active area of research as no inhibitors have yet to...
More importantly, down-regulated ANXA1 inhibited the activation of STAT3 signaling pathway, which thereby suppressed VEGF expression. With this all taken into account, the present study presents that up-regulated ANXA1 inhibits PMN infiltration and MPO activity by activation of STAT3 signaling pathway ...
More importantly, down-regulated ANXA1 inhibited the activation of STAT3 signaling pathway, which thereby suppressed VEGF expression. With this all taken into account, the present study presents that up-regulated ANXA1 inhibits PMN infiltration and MPO activity by activation of STAT3 signaling pathway ...