虽然研究结果表明TRAIL处理对TRAIL- R /SHP-1/Lck复合体有影响,并且与SHP-1磷酸化增强有关,但SHP-1磷酸化对Lck活性的实际作用仍不清楚,需要进一步深入探索以阐明这些微簇成分的空间和动力学关系,以解决TCR复合体、Lck、TRAIL- R和SHP...
因此,TAOK3对SHP-1丰度的调节作为T细胞受体(TCR)信号的调节器,决定了T淋巴细胞的激活阈值。 研究结果表明,TAOK3是一种对TCR信号至关重要的丝氨酸和苏氨酸激酶。它的缺失导致TCR信号减少,并且酪氨酸磷酸酶SHP-1与激酶LCK的相互作用增加,LCK是TCR信号的关键下游介质(图1B)。 图1.A:SHP-1-TAOK3相互作用模型结...
process (2). shp-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-kit, csf-1, egf), cytokine receptors (il-3, ifn-a/b) and other tyrosine based receptor cd22, b & t cell ag receptor, lck, zap-70 and vav (3...
t细胞中磷酸酶的存在对t细胞的功能发挥具有重要的调节作用。t细胞通过tcr-mhc复合物识别抗原之后,胞内大量信号分子会被lck、zap70等激酶磷酸化而激活,参与信号的传递。然而为了维持稳态、防止t细胞的过度激活,t细胞中大量抑制性磷酸酶也会被激活,造成信号分子的去磷酸化而失活,影响了t细胞激活信号的传递,最终削弱了t细胞...
receptor Ig-� subunit (39), killer cell inhibitory receptor =-=(40)-=-, platelet endothelial cell adhesion molecule-1 (41), IL-2R� (42), and CD72 (43), as well as other intracellular proteins such as JAK1 and JAK3 (42), JAK2 (44), ZAP-70 (45), and p56 lck (46). ...
We found that LCK recruited into the synapse of CD28-encoding CAR by co-receptors causes antigen-independent CAR-CD3ζ phosphorylation and increased antigen-dependent T cell activation. In contrast, the synapse formed by 4-1BB-encoding CAR recruits the THEMIS-SHP1 phosphatase complex that ...
2015-05-30上传 SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages 文档格式: .pdf 文档大小: 213.49K 文档页数: 9页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 待分类 文档标签: inIn帮助SHP1TNFandiNOSLPS ...
1e)24. To generate T cells lacking all PKD isoforms, we established T cell-specific PKD2/PKD3 double-deficient mice using Lck-Cre Tg mice (PKD2/3ΔT) (Fig. 2a,b). We confirmed that none of the three PKD isoforms was expressed in PKD2/3ΔT thymocytes using Abs reacting with PKD1, ...
Veillette, A., Bookman, M.A., Horak, E.M. & Bolen, J.B. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.Cell55, 301–308 (1988). CASPubMedGoogle Scholar Download references ...
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