虽然研究结果表明TRAIL处理对TRAIL- R /SHP-1/Lck复合体有影响,并且与SHP-1磷酸化增强有关,但SHP-1磷酸化对Lck活性的实际作用仍不清楚,需要进一步深入探索以阐明这些微簇成分的空间和动力学关系,以解决TCR复合体、Lck、TRAIL- R和SHP...
LCK能够增强CAR-T效果,SHP1能够减少细胞因子的释放,避免CRS的发生2020年2月10日/医麦客 eMedClub/--CAR-T疗法已被证明对血癌有效,即使在实体瘤领域,CAR-T疗法也显示了其强大的潜力,但关于CAR-T疗法的毒性作用也一直如鲠在喉。 近日,来自北卡罗来纳大学教堂山分校的研究人员于Cancer Cell杂志上发表的文章中,提...
Binstadt, BA, et al.Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 1996. 5 :629-638. View this article via:Binstadt BA, Brumbaugh KM, Dick CJ, et al. Sequential involvement of Lck and SHP-1...
process (2). shp-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-kit, csf-1, egf), cytokine receptors (il-3, ifn-a/b) and other tyrosine based receptor cd22, b & t cell ag receptor, lck, zap-70 and vav (3...
t细胞通过tcr-mhc复合物识别抗原之后,胞内大量信号分子会被lck、zap70等激酶磷酸化而激活,参与信号的传递。然而为了维持稳态、防止t细胞的过度激活,t细胞中大量抑制性磷酸酶也会被激活,造成信号分子的去磷酸化而失活,影响了t细胞激活信号的传递,最终削弱了t细胞的杀伤功能[2]。细胞中有一百多种ptp磷酸酶,即使人类...
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells. The phosphorylation and dephosphorylation of proteins on tyrosyl residues are key regulatory mechanisms in T-cell signal transduction and are controlled by... U Lorenz,KS Ravichandran,D Pei,... - 《...
1e)24. To generate T cells lacking all PKD isoforms, we established T cell-specific PKD2/PKD3 double-deficient mice using Lck-Cre Tg mice (PKD2/3ΔT) (Fig. 2a,b). We confirmed that none of the three PKD isoforms was expressed in PKD2/3ΔT thymocytes using Abs reacting with PKD1, ...
pd-1招募的shp-2抑制了pd-1邻近的tcr的磷酸化活化,导致tcr-lck介导的cd3、zap-70等信号分子磷酸化减弱,t细胞激活受到抑制。从而增强肿瘤细胞的免疫耐受性,这是肿瘤细胞免疫逃逸机制的重要组成部分。因此,靶向抑制pd-l1/pd-1信号通路是一种有潜力的癌症治疗策略。
we identify THEMIS as an uncharacterized substrate for the phosphatase SHP1. Saturated mutagenesis assays and mass spectrometry analysis reveal that phosphorylation of THEMIS at the evolutionally conserved Tyr34 residue is oppositely regulated by SHP1 and the kinase LCK. Similar toTHEMIS−/−mice,TH...
2015-05-30上传 SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages 文档格式: .pdf 文档大小: 213.49K 文档页数: 9页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 待分类 文档标签: inIn帮助SHP1TNFandiNOSLPS ...