short‐chain fatty acidsSCFAs are primarily produced in the colon by bacterial fermentation of nondigestible carbohydrates. Besides providing energy, SCFAs can suppress development of colon cancer. The mechanism, however, remains elusive. Here, we demonstrate that the SCFA propionate upregulates surface ...
of IECs. SCFAs affect intestinal motility, barrier function, and host metabolism. Furthermore, SCFAs play important regulatory roles in local, intermediate, and peripheral metabolisms. Acetate, propionate, and butyrate are the major SCFAs, they are involved in the regulation of immunity, apoptosis, ...
Short-chain fatty acids (SCFA) are fatty acids with aliphatic tails of five or fewer carbons (e.g. Butyric Acid). SCFAs play a vital role in maintenance of colonic integrity and metabolism. 中文解释 短链脂肪酸 (SCFAs) 是含有 5 个或更少碳的脂肪尾的脂肪酸 (例如 Butyric Acid)。SCFAs 在维...
and found consistent beneficial effects on steady state and postmenopausal bone metabolism highly related to SCFA levels. It should be also mentioned that the source and biological function of SCFA is essentially different from long-chain fatty acids, which influence insulin metabolism and where effects...
Effects of short-chain fatty acid on proliferation, metabolic poise, and activation capacity of T cellsBackground & Aim T cell Immunotherapy highly relies on optimal activation and differentiation conditions. Cellular metabolism is one of the key factors determining fate and fitness as T cells ...
Unlike hexoses in the small intestine, short-chain fatty acids are partly metabolized in the colonic cells, and appear to be a major nutrient source. Most of the fatty acids are metabolized intracellularly to CO2. Estimates of the contribution of short-chain fatty acid metabolism to the basal ...
Short chain fatty acid and glucose metabolism in isolated pig colonocytes: modulation by NH 4 + B, Cherbuy C, Morel MT, Durand M & DueAe PH (1996) Short-chain fatty acid and glucose metabolism in isolated pig colonocytes: modulation by NH4+... B Darcy-Vrillon,C Cherbuy,MT Morel,....
FFAR3 deficiency abolishes dietary short-chain fatty acid (SCFA) intake-induced expression change of hepatic lipid metabolism-related genes. Hepatic triglycerides contents (A) and mRNA expression levels of hepatic lipid metabolism-related genes (B) inFfar3−/−andFfar2−/−mice (n = 7...
Short-chain fatty acids (SCFAs) and medium-chain fatty acids (MCFAs) are important energy-supplying metabolites. They are also signaling molecules involved in the regulation of carbohydrate and lipid metabolism, as well as mediators of the gut microbiome-immune axis and the gut-brain axis. ...
Microbiome genetics links short-chain fatty acids to metabolic diseases Cristina Menni Ana M. Valdes Nature MetabolismNews & Views26 Mar 2019 Nature Genetics (Nat Genet)ISSN1546-1718(online)ISSN1061-4036(print) Sign up for theNature Briefingnewsletter — what matters in science, free to your inbo...