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anti-CD11a, anti-CD33, anti-CD20, anti-CTLA-4, anti-T cell CD3 Receptor, anti-α-4 (α4) integrin, anti-Immunoglobulin E, anti-RSV F protein, anti-epidermal growth factor receptor, anti-VEGF-A, anti-ErbB2, anti-IL-12/IL-23, anti-integrin α4β7, anti-CD274, anti-3-amyloid, ...
(ix) —CONR10aR11a, and (x) —(NR10a)CO2R9, (b) phenyl or heterocycle, wherein heterocycle is selected from: pyridyl, pyrimidinyl, pyrazinyl, thienyl, pyridazinyl, pyrrolidinyl, azetidinyl, piperidinyl and morpholinyl, which phenyl or heterocycle is unsubstituted or substituted with 1-3 ...
Isomer NMR 31P (ppm) LC/MS (M + 1)+ Elution order 11A DMSO-d6, 162 MHz: 24.24 605.3 Faster eluting 11B DMSO-d6, 162 MHz: 24.18 605.3 Slower elutingExample 12Intermediates: N and MIsomer Separation/Purification Conditions:Prep Chiral HPLC: CHIRALPAK-IC, 5×25 cm, 5 um; Mobile ...
It is also contemplated that when used in combination with one or more other active ingredients, the compounds of the present invention and the other active ingredients may be used in lower doses than when each is used singly. Accordingly, the pharmaceutical compositions of the present invention ...
In another embodiment, the at least one Macrocyclic Compound and the additional therapeutic agent(s) are administered in doses commonly employed when such agents are used as monotherapy for treating a viral infection. In another embodiment, the at least one Macrocyclic Compound and the additional th...
However, using the flattening film 232 on the TFT substrate 202, the cell thicknesses dt and dr may be made different. FIG. 22B shows another example of the schematic sectional structure of the liquid crystal display device according to this basic structure. As shown in FIG. 22B, on the ...
To prevent this it is necessary to image the specimen at very low electron doses; however, this can result in an extremely low signal-to-noise ratio (SNR), and hence very noisy TEM images. We note that TEM images are generally corrupted by both Poisson and Gaussian noise. In addition ...