The shape and structure of proteinsAlberts, BruceAlberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002) The shape and structure of proteins. In: Molecular biology of the cell. Garland Sciences, New York, Fig. 3.1
and the ambitious, Berlin-based Protein Structure Factory, which was investigating human proteins, closed after it failed to secure more funding in 2004. But the rate at which structures are being published is starting to accelerate
The Protein Folding Problem and Tertiary Structure Prediction A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiar... B Boston 被引量: 2735发表: 1995年 The structure and regulation of ...
Study the interactions between proteins (higher order structure), including stability and aggregation pathways Determine protein complexes size, molecular weight and degree of folding Access the structure of intrinsically disordered proteins and RNA and quantify movements of flexible domains Analyze the struct...
Self-Organizing Fuzzy Graphs for Structure-Based Comparison of Protein Pockets Patterns of receptorligand interaction can be conserved in functionally equivalent proteins even in the absence of sequence homology. Therefore, structural... Felix,Reisen,Martin,... - 《Journal of Proteome Research》 被引量...
firststructureofaprotein,haemoglobin Theconsortium'sachievementissaluted (M.F.Perutzetal.Nature185, bythePSI'scoordinator,John 416–422;1960).Andincreas- ing availability of genome sequenceinformationinthe "Crackingfifty structuresinless Norvell."Everystepinthe processisharderforhuman proteins,"saysNorvell...
Proteins are at the core of virtually all cellular processes. Therefore, comprehensive knowledge of protein structures with atomistic detail can be beneficial for several pharmaceutical applications such as vaccine design1, drug discovery2,3, enzyme design4, self-assembling molecular machines5, and many...
structure of protein: the amino acid sequence Primary Structure & Protein Trafficking The rest of the completed polypeptide leaves the ribosome and folds into its final conformation. Polypeptide synthesis begins on a free ribosome in the cytosol. An SRP binds to the signal peptide, halting synthesis...
Correlated mutations and contact in proteins The maintenance of protein function and structure constrains the evolution of amino acid sequences. This fact can be exploited to interpret correlated muta... U Göbel,C Sander,R Schneider,... - 《Proteins Structure Function & Bioinformatics》 被引量:...
The recognition of specific DNA sequences by proteins is thought to depend on two types of mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily in the major groove, and one involving sequence-dependent deformations of the DNA helix. By comprehensively analysing...