抗HUMAN CD70 (SGN-CD70A) 单克隆抗体生产厂家 全球有 1家供应商抗 HUMAN CD70 (SGN-CD70A) 单克隆抗体国内生产厂家 供应商联系电话电子邮件国家产品数优势度 武汉佰乐博生物技术有限公司027-65279366 18108604862products@biolabreagent.com中国981858
We have developed a humanized anti-human CD70 monoclonal antibody, SGN-70, that can selectively deplete CD70+ antigen-specific T cells and down-regulate expression of cytokines and chemokines including IFN-纬, TNF-伪, VEGF and IP-10, as well as the co-stimulatory molecules CD40L, 4-1BB, ...
Conclusions The modest antitumor activity of SGN‐CD70A does not support its development in mRCC. However, given the high disease control rate in a heavily pretreated population and the modest toxicity profile, CD70 remains of interest because of its immunomodulatory properties....
CD70+ tumour cell lines were used for testing the anti-tumour activity of the anti-CD70 antibody–drug conjugate, SGN-75. We report novel detection of CD70 expression in multiple cancers including pancreatic (25%), larynx/pharynx (22%), melanoma (16%), ovarian (15%), lung (10%), ...
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Background Cluster of differentiation 70 (CD70) is frequently expressed in renal cell carcinoma (RCC) and has immunomodulatory properties. An antibody‐drug conjugate targeting CD70, SGN‐CD70A, was developed to treat patients with CD70‐positive RCC. Methods The objective of this phase 1, open...