SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug- resistant AML. Blood. 2013;122(8):1455-1463.Kung Sutherland MS, Walter RB, Jeffrey SC, Burke PJ, Yu C, Kostner H, et al. SGN-CD33A: a novel CD33-targeting ...
The cell surface antigen CD33 is expressed on the majority of AML blasts and is appropriate for immunotherapeutic targeting with antibody drug conjugates (ADCs). Expression of CD33 is in part mediated by splicing of the CD33 transcript, and has been demonstrated to be one of the factors that ma...
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not assoc...
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not assoc...
Voi, Sgnor, Che Giusto Siete 2013-11-11 19:15:2404:39 29 所属专辑:古典音乐 - Volume 9(CD33) Le Nozze di Figaro KV 492 Part 2 喜欢下载分享 用户评论 表情0/300发表评论 暂时没有评论,下载喜马拉雅与主播互动音频列表 1 Aprite, Presto, Aprite 452013-11 2 Esci, Ormai, Garzon Malnato 552013...
Interim Analysis of a Phase I Trial of SGN-CD33A in Patients with CD33-Positive Acute Myeloid Leukemia (AML). 56th ASH Annual Meeting and Exposition; 6th-9th December, 2014; Moscone Centre, San Francisco2014.Stein EM, Stein A, Walter RB et al. Interim analysis of a phase 1 trial of ...
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conjugate SGN-CD33A. This genotype, for the CD33 splice site SNP rs12459419, was not ...
A phase 1 trial of SGN- CD33A as monotherapy in patients with CD33-positive acute myeloid leukemia (AML). Blood. 2015;126:324.Stein AS, Walter RB, Erba HP, Fathi AT, Advani AS, Lancet JE, et al. A phase 1 trial of SGN-CD33A as monotherapy in patients with CD33-positive acute ...