[4]O'Meara E, McDonald M,Chan M,et al.CCS/CHFS Heart Failure Guidelines: Clinical Trial Update on Functional Mitral Regurgitation, SGLT2 Inhibitors,ARNl in HFpEF, and Tafamidis in Amyloidosis[]]Can J Cardiol,2020,36(2):159-169. [5]廖梦阳...
SGLT2 inhibitors (SGLT2i) are new drugs for patients with heart failure (HF) irrespective of diabetes. However, the mechanisms of SGLT2i in HF remain elusive. This article discusses the current clinical evidence for using SGLT2i in different types of heart failure and provides an overview ...
Patients with heart failure and preserved ejection fraction (HFpEF) have a high burden of symptoms and functional limitations, and have a poor quality of life. By targeting cardiometabolic abmormalities, sodium glucose cotransporter 2 (SGLT2) inhibitors may improve these impairments. In this multic...
SGLT2 is not expressed on the heart [78], yet there is strong pre-clinical evidence that SGLT2-inhibitors influence Ca2+handling by modulating intracytoplasmic Na+in the cardiomyocyte. This is supported by evidence that empagliflozin improves SERCA2a efficiency [79] and reduces RyR2-dependent Ca2+...
Investigators found that sodium-glucose contrasporter-2 (SGLT2) inhibitors demonstrated effectiveness for the primary and secondary prevention of heart failure (HF) across a broad range of care settings and patient populations. irissca - stock.adobe.com The results of a review, published in Cureus...
一项研究报告称,在基线高尿酸血症患者中,SGLT2 抑制剂治疗可显著降低这些结局的风险【Eur. Heart J. 43, 3435–3446 (2022)】,据推测,这种情况在大多数痛风患者都会存在【JAMA Cardiol. 8, 386–393 (2023)】。这些数据是有希望的;...
Heart failure hospitalizations are due to congestion in 90% of the cases. SGLT-2 inhibitors reduce the rate of decline in renal function among diabetic patients.33 This could be relevant in decreasing HF hospitalizations. By lowering blood pressure, increasing aortic compliance and improving ventricula...
This document explores the use of SGLT2 inhibitors as a first-line treatment for heart failure with reduced ejection fraction (HFrEF). While studies have shown that these inhibitors can improve symptoms and reduce hospitalizations for heart failure, there is limited evidence of their effectiveness in...
Both heart failure and diuretic or SGLT2 inhibitor use increase fall risk in older adults. Diuretics and SGLT2 inhibitors not only have various fall-related adverse effects, which partly overlap (e.g. tendency to cause hypotension), but also differ: compared to SGLT2is, diuretics display more...
Diuretic Action of Sodium-Glucose Cotransporter 2 Inhibitors and Its Importance in the Management of Heart Failure Primarily, the sodium-glucose cotransporter 2 (SGLT2) inhibitors suppress the cotransport of glucose and sodium from the tubular lumen of the proximal tubu... Kimura,Genjiro - 《...