SGLT2 inhibitors therefore provide clinicians with an exciting new treatment option for patients with CKD and heart failure.doi:10.1038/s41581-022-00535-6Annemarie B van der Aart-van der BeekRudolf A de BoerHiddo J L HeerspinkNature Publishing Group UKNature reviews. Nephrology....
1 We recommend temporary discontinuation of SGLT-2 inhibitors when treating acute pyelonephritis or urosepsis (see sick-day guidance 1C in Section 5a.1.2 of the supplementary appendix) CHILDREN, PREGNANCY AND BREASTFEEDING 1 We suggest that all women of child-bearing potential are counselled, prior ...
SGLT2 is not expressed on the heart [78], yet there is strong pre-clinical evidence that SGLT2-inhibitors influence Ca2+handling by modulating intracytoplasmic Na+in the cardiomyocyte. This is supported by evidence that empagliflozin improves SERCA2a efficiency [79] and reduces RyR2-dependent Ca2+...
1 We recommend temporary discontinuation of SGLT-2 inhibitors when treating acute pyelonephritis or urosepsis (see sick-day guidance 1C in Section 5a.1.2 of the supplementary appendix) CHILDREN, PREGNANCY AND BREASTFEEDING 1 We suggest that all women of child-bearing potential are counselled, prior ...
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by direct action on the failing heart that is independent of changes in renal tubular function. In the failing heart, nutrient transport into cardiomyocytes is increased, but nutrient utilization is impaired, leading to def...
Patients with heart failure and preserved ejection fraction (HFpEF) have a high burden of symptoms and functional limitations, and have a poor quality of life. By targeting cardiometabolic abmormalities, sodium glucose cotransporter 2 (SGLT2) inhibitors may improve these impairments. In this multic...
钠-葡萄糖共转运蛋白2抑制剂(sodium-glucose co-transporter 2 inhibitors,SGLT2i)作为一种有效的治疗2型糖尿病(type 2 diabetes mellitus,T2DM)的药物,主要通过防止葡萄糖在肾脏的重吸收,促进葡萄糖在尿液中的排泄,达到降糖的效果。同时也对心血管患者有益,特别是心力衰...
SGLT-2 inhibitorsType 2 diabetescardiovascular outcomeheart failure hospitalizationHeart failure (HF) in type 2 diabetes mellitus (T2DM) poses a significant increase in mortality. Until recently, anti-diabetic drugs have not been shown to reduce hospitalization due to heart failure (hHF). While ...
[15].Efficacy and Safety of Sodium-Glucose Co-transporter-2 Inhibitors in Acute Heart Failure: A Meta-Analysis of Randomized Controlled Trials. AHA 2024. 本材料由阿斯利康提供,旨在满足您的医学信息需求,仅供医疗卫生专业人士参考,不用于推广目的。
[4]O'Meara E, McDonald M,Chan M,et al.CCS/CHFS Heart Failure Guidelines: Clinical Trial Update on Functional Mitral Regurgitation, SGLT2 Inhibitors,ARNl in HFpEF, and Tafamidis in Amyloidosis[]]Can J Cardiol,2020,36(2):159-169.