Arthur L M SwislockiIshwarlal JialalHalimi S, Verges B. Adverse effects and safety of SGLT-2 inhibitors. Diabetes Metab. 2014;40:28-34.
In some clinical trials, SGLT2 inhibitors exerted cardiovascular and kidney protective effects, which appeared to be...doi:10.1038/s41581-018-0028-0Blau Jenny E.Taylor Simeon I.Nature Reviews NephrologyBlau JE, Taylor SI: Adverse effects of SGLT2 inhibitors on bone health. Nat Rev Nephrol 14:...
SGLT2 inhibitors improve hyperglycemia with a decline in body weight and blood pressure, the outcomes touted to be of major importance in management of type 2 diabetes. However, the efficacy in lowering glycemia is very modest and imparts an undue cost burden on patients. Moreover, the ...
[8] Packer M.(2020). Cardioprotective effects of Sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (Sodium-Glucose Cotransporter 2) inhibitors, Circ Heart Fail, 13(9), e007197. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007197 [9] ...
2.Chaosheng Chen, Ji Zhang, Gengru Jiang, et al. Baseline Characteristics and Associations of Using SGLT2 Inhibitors in IgA Nephropathy in China: Results from the CPO-IGAN. ASN 2024, FR-PO861. 3.KDIGO 2024 Clinical P...
The results of EMPULSE add to the accumulating evidence on the benefits of SGLT2 inhibitors in heart failure9,10,11,12,13,14. EMPULSE is distinct from previous trials with SGLT2 inhibitors for several reasons. In particular, patients in EMPULSE were randomized early in the course of ...
Sodium–glucose cotransporter 2 (SGLT2) inhibitors were initially developed for their glucose-lowering effects and have shown a modest glycaemic benefit in people with type 2 diabetes mellitus (T2DM). In the past decade, a series of large, robust clinica
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and reduce renal reabsorption of sodium and glucose. While many clinical trials demonstrated the tremendous potential ...
[13]. Hiddo J L Heerspink, et al. Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.Circulation,2016 Sep 6;...
Both heart failure and diuretic or SGLT2 inhibitor use increase fall risk in older adults. Diuretics and SGLT2 inhibitors not only have various fall-related adverse effects, which partly overlap (e.g. tendency to cause hypotension), but also differ: compared to SGLT2is, diuretics display more...