The inhibition of SGLT2 does not lead to side effects, which always observed with traditional drugs,and it is a new approach for developing antidiabetis agents. In this paper,the mechanism,structure and activity relationship and new progress of SGLT2 inhibitors are reviewed.%钠-葡萄糖协同转运...
Traditional treatments for type 1 and type 2 diabetes are often associated with side effects, including weight gain and hypoglycaemia that may offset the benefits of blood glucose lowering. The kidneys filter and reabsorb large amounts of glucose, and urine is almost free of glucose in normoglyc...
In March 2017, dapagliflozin became the first SGLT2i approved for use in China. Additionally, sotagliflozin, the first dual SGLT2/1 inhibitor, improves glycated hemoglobin in adults with diabetes, with beneficial effects on body weight and blood pressure [16]. Table 1 Brief introduction to the...
A less common yet equally important side-effect associated with SGLT2i is DKA. SGLT-2 associated DKA is not an extensively studied phenomenon4. DKA is more common in type 1 diabetes mellitus (T1D) than T2D (50–100 and 4.6–8 episodes per 1000 patients, respectively)5,6. However, it...
分类号:。621、9密级:山东单位代码:10422学号:2010202牛D只季UNIVERSITY博士学位论文DissertationforDoctoral..
This suggests that the side effects of SGLT-2i on the metabolism and nutrition system are also worthy of our attention. In our study, there was an equal proportion of men and women in the population that used SGLT2-i and had side effects (Supplementary Table 4). Age groups are mainly ...
This has led to the discovery of novel therapeutic agents in treating T2DM that limits the side effects of existing drugs at the same time improving glycemic control. The vital role of kidneys in maintaining glucose homeostasis has given the impetus in developing sodium glucose co-transporter2...
Secondly, we determine the sufficient and necessary conditions for optimal control strategy of SGLT-2 inhibitors so as to avert side effects on normal cells using a Pontryagin's Minimum Principle. The results showed that if the ingestion rate of the inhibitor drug is equal to the digestion rate...
Nonpharmacologic and pharmacologic management strategies are also included to manage genitourinary side effects of SGLT2i and optimize bladder function and possibly minimize LUT dysfunction. 展开 关键词: bladder dysfunction Fournier gangrene genitourinary infections lower urinary tract dysfunction SGLT2 ...
the hyperglycemia still can't be controlled even accompanied by side effects.Therefore new agents with novel mechanisms of action are urgently needed.In recent years,researchers have discovered anew mechanism of glycemic control that inhibition of SGLT2 is able to suppress the reabsorption of glucose ...