Fatness parameters, measured by dual-energy X-ray absorptiometry, lipid profile, insulin, leptin, sex steroid hormones and sex hormone-binding globulin (SHBG) levels were compared at baseline and 1 year after the beginning of the study. The data showed that plasma SHBG levels, but not ...
The aim of the this study was to evaluate the association between early pregnancy levels of serum sex hormone-binding globulin in the first trimester and the development of gestational diabetes mellitus (GDM). Currently, no effective markers in early pregnancy have been established to identify women...
Exogenous hormones are used by more than a hundred million women worldwide as oral contraceptives or for postmenopausal hormone replacement. Oral contracep... FR Rosendaal,FM Helmerhorst,JP Vandenbroucke - 《Arteriosclerosis Thrombosis & Vascular Biology》 被引量: 890发表: 2002年 A Reduced Sensitivi...
SHBG（性激素结合球蛋白）是一种重要的蛋白质，在体内具有调控性激素生物活性的重要作用。SHBG主要由肝脏合成，其主要功能是将性激素如雄激素和雌激素结合并在体内循环，从而调节这些性激素的生物活性，影响性激素的代谢和分布。目录号 PA1000-8935 在研究性激素相关疾病和药物开发过程中，重组SHBG蛋白被广泛应用。重...
Sex hormone-binding globulin (SHBG) levels in serum are affected by thyroid status; hyperthyroidism is associated with high SHBG levels, whereas hypothyroid patients have low or normal SHBG levels. This study was undertaken to test the usefulness of SHBG determinations to define the thyroid status ...
The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). RESULTS: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significant difference in free ...
Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues. Still, thein vivophysiological role of circulating SHBG remains...
Background: SHBG levels are low in obesity, and low SHBG levels are a biomarker for the development of T2DM and the metabolic syndrome. We sought to determine whether low SHBG in newborns will predict childhood obesity. Methods: We studied 94 healthy, singleton, full-term newborns, and measure...
Plasma sex hormone-binding globulin levels decrease during the second decade of life irrespective of pubertal status The plasma concentrations of sex hormone-binding globulin (SHBG) and sex steroids determine the nonprotein bound or free steroid fraction, which probably exerts the biological activity of...
In in vitro experiments increased levels of SHBG will be associated with decreased levels of non-SHBG bound testosterone (non-SHBG-T). However, in vivo SHBG can alter both production and clearance rates and thus plasma levels of T.关键词: Humans Testosterone Sex Hormone-Binding Globulin Linear ...