Ischemic small vessel disease (SVD) is a common finding on routine scans in older people, but cognitive sequelae vary considerably. To improve understanding of mechanisms underlying decline or preservation of cognitive function in this condition, we assessed cognition and cortical plasticity in 20 ...
Small vessel vasculitis and ischemic injury leading to activation of proteolytic enzymes and auto-digestion is a possible mechanism [12]. All the patients described in the current series, were hemodynamicaly unstable at presentation or within the first 24 h of hospital stay. Refractory hypotension ...
Smaller scale case series reported cerebral edemas but also ischemic, hemorrhagic, bithalamic lesions, isolated lesions of the white matter, or even non-specific lesions. Correlation between imaging results and clinical signs still needs to be clarified and no prospective study has been performed in...
Coronary artery disease (CAD) is one of the most common cardiovascular diseases in the world, leading to severe life-threatening cardiovascular events such as acute myocardial infarction (MI), malignant arrhythmia, and heart failure [1, 2]. Timely treatment of CAD can improve the prognosis and ...
Further progression of PE to sPE poses a serious threat to maternal and infant health and safety. In sPE, small vessel spasm leads to endothelial injury, local ischemia, and insufficient perfusion of systemic organs, resulting in weak uterine contractions, which leads to PPH [16]. PPH is one...
Groundbreaking study results since 2014 have dramatically changed the therapeutic options in acute therapy for severe ischemic stroke caused by large vessel occlusion (LVO). The scientifically proven advances in stroke imaging and thrombectomy techniques have allowed to offer the optimal version or combinat...
Truncating mutations in murine Col4A1 result in cerebral hemorrhage in both neonatal and adult mice, and mutations have been reported in infants with congenital porencephaly, fetal IVH, and adults with cerebral small vessel disease (35,76). More recently, mutations have also been reported in ...
The majority (80–85%) of strokes are ischemic, in which a blood clot cuts off the blood supply to a region of the brain. The other 15–20% are hemorrhagic, in which a blood vessel bleeds into a region of the brain, severely disturbing brain function. By measuring oxidative stress via...
and adults with cerebral small vessel disease (35,76). More recently, mutations have also been reported in preterm neonates with IVH (77,78). Studying 41 preterm infants with IVH, Bilguvaret al. (79) identified a rare heterozygous duplication within a highly conserved residue inCOL4A1in dizyg...
Subdural hematoma decompression model: a model of traumatic brain injury with ischemic-reperfusional pathophysiology: a review of the literature. Behav Brain Res. 2018;340:23–8. Article PubMed Google Scholar Schwarzmaier SM, de Chaumont C, Balbi M, Terpolilli NA, Kleinschnitz C, Gruber A,...