Background: We estimated the prevalence and incidence of amyloid-尾 deposition (A), small-vessel disease (V), and neurodegeneration (N) biomarker positivity in community-dwelling cognitively normal individuals (CN). We determined the longitudinal association between the respective bioma...
Small Vessel Cerebrovascular Pathology Identified by Magnetic Resonance Imaging Is Prevalent in Alzheimer's Disease and Mild Cognitive Impairment: A Potent... There is evidence that Alzheimer's disease (AD) has significant cerebrovascular etiopathogenesis. Understanding potentially modifiable risk factors for...
FDa = arteriolar fractal dimension; VRF = vascular risk factor; WMH = white matter hyperintensities; SVD = small vessel disease. Dashed lines represent non-significant associations. Full size image We tested additional SEMs—to test for co-association of retinal and SVD ...
The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we report the presence of large Aβ aggregates in plasma from pat...
have been described3. Impaired cerebral glucose metabolism37, mitochondrial dysfunction, and increased oxidative stress have all been observed8. In addition to neurodegenerative brain changes, dementia is frequently associated with vascular pathologies such as small vessel disease (multiple or single infarcts...
Association Between Traumatic Brain Injury (TBI) and Cerebral Small Vessel Disease (SVD) eTable 4. Association Between Traumatic Brain Injury (TBI) and Clinical Features Supplement 2. Nonauthor Collaborators Supplement 3. Data Sharing Statement 1. Livingston G, Huntley J, Somme...
Ischemic brain lesions associated with hypertension (HTN). HTN induces atherosclerosis of major extracranial and intracranial arteries, which could lead to major infarcts. HTN causes both microbleeds and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar ...
7. aMCI is a cognitive stage that falls between the normal aging process and the onset of dementia1. It is worth noting that the annual conversion rate from aMCI to Alzheimer’s disease (AD) is approximately 16.5%. Nevertheless, a small percentage of patients with aMCI (8%) exhibit a ...
et al. Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model. Neuroscience. 408, 361–377. https://doi.org/10.1016/j.neuroscience.2019.04.018 (2019). Article CAS PubMed Google Scholar Madrigal, J. L., Leza, J. C., ...
Compared with NC patients, those with MCI were older (MCIvs. NC: median years, 77vs. 69,P < 0.001), had a higher prevalence of hypertension (63.9%vs. 38.1%,P = 0.045) and were more likely to present with indications of cerebral small vessel disease (SVD), such as white ma...