It is becoming increasingly evident that cerebral dysfunction and outcome after severe (i.e., Glasgow Coma Scale — GCS ≤ 8) head injury (SHI) are related, as a rule, not only to the initial structural injury to the brain, but also to a variety of secondary pathophysiological mechanisms,...
Promoting mitophagy plays protective roles in neuromuscular disease, cancer, and ischemic diseases [9]. In recent years, an increasing number of studies have indicated the intricate association between infection and mitophagy. Therefore, we review the new researches about the mechanism of the mitophagy...
The pathophysiological sequelae of renal damage, such as uremia, inflammation, and microvascular dysfunction, can lead to myocardial hypertrophy and interstitial fibrosis. These changes contribute to right ventricular dysfunction and enlargement, potentially accelerating the progression of late TR [24]. More...
Relative contributions of macrovascular and microvascular dysfunction to disease severity in falciparum malaria J Infect Dis, 206 (4) (2012), pp. 571-579 CrossrefView in ScopusGoogle Scholar [84] J. Hanson, S.W.K. Lam, S. Alam, R. Pattnaik, K.C. Mahanta, M. Uddin Hasan, et al. Th...
Such contractions are not attenuated with the restoration of arterial flow but are manifested as continuous microvascular vasoconstriction, which affects the flow of blood to the veins. The stagnation of capillary blood flow also causes neutrophil adhesion, thereby resulting in blood vessel blockage and...
Several studies have revealed the relevance of the TyG index and cardiovascular disease. A higher TyG index is linked to an increased risk of cardiovascular events, cerebrovascular events, and kidney microvascular damage [7,8,9], as well as inflammation, endothelial dysfunction, oxidative stress, ...
use of cholesterol-lowering medication (statin or other), and history of peripheral arterial disease, hypertension, dyslipidemia, or microvascular disease (diabetic retinopathy, diabetic neuropathy, or diabetes with renal manifestations; end-stage renal disease; or dialysis) before surgery (defined based ...
Alternatively the major events, amputation and death, that we recorded as primary outcome could be mostly brought about by macrovascular arterial disease, whereas endothelial damage is mostly related to microvascular disease. The present study has several limitations: firstly we only recorded all-cause ...
13,15,16 Since pathophysiological conditions such as infection, sepsis, inflammation, and ischemic disease can cause thrombomodulin release from the endothelial cell membrane into the blood, soluble thrombomodulin is considered as a useful biomarker to diagnose endothelial damage and dysfunction.11,12 ...
Pattern of DE in Chagas' disease may mimic that of both ischemic and nonischemic cardiomyopathies, with especial predilection for the apical and infero... A Regueiro,A García-Álvarez,M Sitges,... - 《International Journal of Cardiology》 被引量: 66发表: 2013年 Efficient Transmural Cardiac...