Sertoli cells also respond to pituitary hormones such as follicle-stimulating hormone (FSH) to begin the process of spermatogenesis, supplementing the adjacent spermatogonia.[3][4][5] Sertoli cells are so important that their mere absence in the testes can lead to infertility in adult men even ...
The Sertoli-Leydig cell tumors of the ovary, also called androblastomas, belong to the group of the sex cord stromal tumors. Although apparently pure Sertoli or Leydig cell tumors do occur, most of the androblastomas are composed of both Sertoli and Leydig cells and exhibit, at least focal...
were mainly seen in the elongated spermatids, while TGFβ-RⅡ in the pachytene spermatocytes and weak in the spermatogonia, spermatids and Sertoli cells... JZ Ruo-Junxu - 《亚洲男性学杂志(英文版)》 被引量: 81发表: 2004年 Type II and type IX collagen transcript isoforms are expressed during...
Currently there are no models to study mechanisms of virus persistence in the seminiferous tubules. We provide evidence that ZIKV infection of human Sertoli cells, important component of the seminiferous tubules, is robust and induce strong antiviral response. The use in vitro Sertoli cell barrier ...
Some genes identified in the AZF locus are expressed only in germinal cells; others are ubiquitous. AZF microdeletions seem to occur at the earliest stages of ontogenetic development, and one might therefore assume that Sertoli cells preserve some immature characteristics and that their immunophenotype ...
Mature Sertoli cells take on the classic ‘tree-like’ appearance with branches that surround the associated germ cells (Figure 1) and display the characteristic tripartite nucleus with prominent nucleoli (Russell et al., 1990). Tight junctions are also formed between adjacent mature Se...
(M) Cell counts of SOX9+ cells per tubule in P90 control (Dhh-Cre;Rac1flox/+) versus cKO testes (n = 10 tubules each from 3 independent males). The data in (K)–(M) are shown as means ± SDs. p values were performed via a two-tailed Student’s t test. See also Figures S1...
Germinal cells and seminomas The ultrastructure of the cells of normal germinal epithelium of healthy dogs is described and compared with that of tumour cells of 16 canine seminomas. Both normal and tumour cells are characterized by oval nuclei, straight cell border... DV Bomhard,C Pukkavesa...
► Using Notch reporter mice, we show that Notch signaling is active in Sertoli cells. ► Mutant mice constitutively over-expressing NICD1 in Sertoli cells are sterile. ► Gonocytes start dying at E15.5 due to premature differentiation. ► Factors required for proper gonocyte maintenance...
In the investigation presented here, we find that the rat-derived Sertoli cell line 93RS2 also expresses considerable amounts of the α4 isoform in addition to the α1 isoform. Since Sertoli cells are not motile, one can assume that the function of the α4 isoform in these cells must ...