The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT 3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT 3 receptors is beneficial. Therapy is indicated for, but not ...
SEROTONIN (5HT3) ANTAGONISTS5个回答 羟色胺( 5HT3 )拮抗剂 2013-05-23 12:21:38 回答:匿名5-羟色胺(5HT3)反对者 2013-05-23 12:23:18 回答:匿名5-羟色胺 (5HT3) 反对者 2013-05-23 12:24:58 回答:匿名5-羟色胺 (5HT3) 拮抗剂 2013-05-23 12:26:38 回答:匿名血液中的复合胺 ( 5...
Studies with 5-HT receptor antagonists indicate that the proposed role of particular 5-HT1/2 receptor subtypes in the hypophagic effects of these 5-HT receptor agonists may be more complicated than originally thought. Further characterization of the role of 5-HT1/2 receptor subtypes in the ...
(263), suggesting that serotonin may mediate the effects ofsecretinthrough both 5-HT2 and 5-HT3receptor subtypes. Interestingly, both of theseserotonin antagonistsalso have been reported to inhibit secretin release induced by duodenal acid. Nevertheless, despite these advances, the overall functional ...
RATIONALE: The 5-HT(7) receptor is a more recently discovered G-protein-coupled receptor for serotonin. The functions and possible clinical relevance of th... PB Hedlund - 《Psychopharmacology》 被引量: 473发表: 2009年 The non-antiemetic uses of serotonin 5-HT3 receptor antagonists. Clinical ...
2) 5-hydroxytryptamine receptor antagonists 5-羟色胺(5-HT3)受体拮抗剂3) Serotonin Receptor Antagonist/Reuptake Inhibitor 5-羟色胺受体拮抗剂/再摄取抑制剂4) 5-HT3 recepter antagonist kytril 5-羟色胺第3受体拮抗剂5) 5-hydroxytrptamin3 antagonist palonosetron hydrochloride 5-羟色胺3受体拮抗...
1B), the antibiotics up-regulated the gene expression of TPH1 (P < 0.05), which encoded the rate-limiting enzyme for the synthesis of 5-HT. Among genes encoding 5-HT receptor and metabolic enzymes, antibiotics tended to up-regulate monoamine oxidase A (Maoa) and 5-HT2AR expression...
Opiate receptor antagonists have exhibited cytoprotective activity in preclinical focal and global models of ischemia.131-133 Several small trials of naloxone have not conclusively shown efficacy in acute ischemic stroke.134-138 The equivocal results are likely due to insufficient power of these smal...
Fig. 5.9.5-HT3antagonists developed as antianxiety drugs. Selective serotonin reuptake inhibitors(SSRIs), which work via by blocking the serotonin transporter, an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, are primarily classified...
It has been revealed that serotonin 5-HT3receptor antagonists can inhibit nausea and emesis as side effects caused by the use of cisplatin and the like carcinostatic agents and by radiation treatments, and several compounds thereof are now used in the clinical field. In addition to this, devel...