Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast David Walter, 2010, PhD Thesis, University of Basel Apoptosis is a form of programmed cell death that plays a central role in development and cellular homeostasis in higher eukaryotes. Knowledge about...
2011. The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer en- velope protein. PLoS One 6:e18175.White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC. 2011. The HtrA-like serine protease PepD interacts ...
www.nature.com/cdd The mitochondrial serine protease HtrA2/Omi: an overview L Vande Walle1,2, M Lamkanfi1,2,3 and P Vandenabeele*,1,2 The HtrA family refers to a group of related oligomeric serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction ...
Domain Architectures identified inArabidopsisand rice serine Protease-like proteins. At -Arabidopsis thaliana; Os – Rice (Oryza sativa); B- Bacteria; A- Archaea; E- Eukaryota; Sxx- Serine protease family Sxx domain, where Sxx refers to the serine protease family as per MEROPS [5] classificatio...
HtrA1precursor proteinis 480amino acidsin length and includes an N-terminalsignal peptide(SP, aa 1–22), an insulin/insulin-like growth factor binding domain (IGFBP, aa 37–89, PF00219), a Kazal-type serine protease-inhibitor domain (aa 110-155, PF07648), a trypsin protease domain (aa...
(dipeptidyl-peptidase 4) (p = 6.8e−9, p = 1.1e−15), HTRA1 (high-temperature requirement A serine peptidase 1) (p = 2.22e−16, p = 2.22e−16), PLAU (urokinase) (p = 2.22e−16, p = 2.22e−16), PRSS23 (serine protease 23) (p = 2.22e−16, p = ...
Campylobacter jejuni secretes HtrA (high temperature requirement protein A), a serine protease that is involved in virulence. Here, we investigated the interaction of HtrA with the host protein occludin, a tight junction strand component. Immunofluoresce
High-temperature requirement protease A2 (HtrA2) is a complex trimeric mitochondrial serine protease, which primarily acts as a key player in apoptosis. It belongs to S1 chymotrypsin family that is conserved from microorganisms to humans. The four human HtrA homologues (HtrA1-4) reveal a common ...
HTRA1 belongs to the HTRA serine protease family, which is highly conserved from microorganisms to multicellular organisms, including humans (11). Several cellular and molecular studies have suggested that HTRA1 plays a key role in regulating various cellular processes via the cleavage and/or binding...
Serine peptidase HTRa2, also called Omi stress-regulated endoprotease and Park13, can be released from mitochondria during apoptosis and tether to caspase inhibitors, such as XIAP, IAP1, and IAP2, to cleave them, thereby reducing inhibition to caspase activation. Protein HTRa2 is phosphorylated un...