Serine palmitoyl-CoA transferase (SPT) is the key enzyme in sphingolipid biosynthesis. To evaluate in vivo SPT activity and its role in sphingolipid metabolism, we applied homologous recombination to embryonic stem cells, producing mice with long chain base 1 (Sptlc1) and long chain base 2 (Sp...
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1) Serine Palmitoyl Transferase 丝氨酸棕榈酰转移酶2) serine palmitoyltransferase 丝氨酸棕榈转移酶3) palmitoyl transferase 棕榈酰转移酶 例句>> 4) carnitine palmitoyltransferase 1 肉毒碱棕榈酰转移酶 1. Objective To investigate anticancer effects of a branched-chain fatty acid,13-methyltetradecanoic ...
7.1Serine Palmitoyl Transferase Serineis not the only amino acid to be used bySPTas recent studies have suggested that mutant forms of SPT are able to utilisealanineand glycine. This was discovered after the unravelling of the molecular basis of HSAN1 (Bejaoui et al., 2001), anautosomal domi...
This invention provides compounds of the formula (I) useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred ...
C. Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim. Biophys. Acta 1737, 44–51 (2005). Article CAS PubMed Google Scholar Li, Z. et al. Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases ...
In addition, together with palmitoyl-CoA, serine serves as building block of sphingolipids including ceramides and sphingomyelins and in conditions of limited serine availability, also l-alanine may serve as a substrate for serine palmitoyl transferase reactions [2, 34]. Yet, the effect of ...
Kimberlin, A. N., Majumder S., et al. (2013). Arabidopsis 56-amino acid serine palmitoyl- transferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity. Plant Cell 25 (11): 4627-39.Kimberlin, A.N., Majumder, S., Han, G., Chen, M., ...
3)Serine Palmitoyl Transferase丝氨酸棕榈酰转移酶 4)ornithine acetyltransferases鸟氨酸乙酰转移酶 1.We analyzed the catalysates of ornithine acetyltransferases(OATase) from C.论文以钝齿棒杆菌(Corynebacterium crenatum) JNPH5-8为研究对象,通过对其L-精氨酸合成途径中鸟氨酸乙酰转移酶编码基因argJ的功能分析,考察...
7.1Serine Palmitoyl Transferase Serineis not the onlyamino acidto be used bySPTas recent studies have suggested that mutant forms of SPT are able to utilisealanineand glycine. This was discovered after the unravelling of the molecular basis of HSAN1 (Bejaoui et al., 2001), anautosomal dominant...