Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identif...
Define Sanger sequencing. Sanger sequencing synonyms, Sanger sequencing pronunciation, Sanger sequencing translation, English dictionary definition of Sanger sequencing. n. The determination of the sequence of nucleotides in a sample of DNA. American Her
Our RNA-Seq services provide unparalleled flexibility in analyzing different RNA species, including coding, non-coding, and small transcripts, from a wide range of starting material using long- or short-read sequencing. Various RNA-Seq service options are available, including total, small, and singl...
Whole genome sequencing (WGS) is the comprehensive read and analysis of an entire genome, including non-coding regions of the genome. WGS is used to facilitate discovery of novel genes and gene variants associated with disease. In the case of human WGS, researchers use WGS to explore gene exp...
Firstly, as each native RNA read represents a single polyadenylated RNA transcript that is potentially protein coding, one promising application of dRNA-seq is to identify and quantify the expression of novel transcript isoforms and open reading frames (ORFs). However, the abundance of indel ...
Whole genome sequencing can also identify genetic variants in noncoding regions (promoters, intergenic regions, regulatory regions…). These methods have the advantage of discovering new disease-causing genes and expanding the knowledge of the phenotypic spectrum of known disease-causing genes. Lastly, ...
The newly synthesized DNA is isolated from the genomic DNA and used in the downstream NGS reaction. Large portions of the genome may be captured with these technologies; eg, all the known coding regions (known as exome sequencing) or panels of relevant genes related to particular diseases. ...
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Typical assembling programmes return thousands of predicted contigs, whose connection to the species true gene content is unclear, and from which SNP definition is uneasy. Here, the transcriptomes of five diverse non-model animal species (hare, turtle, ant, oyster and tunicate) were assembled from...
et al. Progression in smoldering Waldenstrom macroglobulinemia: long-term results. Blood 119, 4462–4466 (2012). Article CAS PubMed PubMed Central MATH Google Scholar Owen, R. G. et al. Clinicopathological definition of Waldenstrom’s macroglobulinemia: consensus panel recommendations from the ...