Here, a sequence-specific nanoparticle barcode (SSNB) method is presented for simultaneous detection of 10 HEV types. This method significantly increases sensitivity, enhancing detection by 10-10 6 times over the traditional multiplex hybrid genotyping (MHG) method, by resolving cross-interference ...
近日,厦门大学夏宁邵、张师音、葛胜祥共同通讯在Nature Communications 在线发表题为“Sequence-specific nanoparticle barcode strategy for multiplex human enterovirus typing”的研究论文,该研究提出了一种序列特异性纳米颗粒条形码(SSNB)方法,用于同时检测10种HE
RNA nanoparticles have been used to harbor tumor-specific ligands displayed on exosome surface. The negative charge reduces nonspecific binding to vital cells with negatively charged lipid-membrane due to the electrostatic repulsion, thus lowering the side-effect and toxicity. In this review, we focus...
No significant difference was observed in secreted albumin with either the ARCUS-POL nuclease or the non-HBV-targeting nuclease, suggesting the reduction in HBsAg is specific to the HBV-targeting nuclease activity (Figure 3F). These data suggest that cutting by ARCUS-POL results predominantly in ...
Sequence-defined macromolecules consist of a defined chain length (single mass), end-groups, composition and topology and prove promising in application fields such as anti-counterfeiting, biological mimicking and data storage. Here we show the potential
The optimization of sequence-defined nanocarriers differs for different nucleic acid cargos as well as their specific applications. Supramolecular self-assembly enriched the development of a virus-inspired non-viral nucleic acid delivery system. Incorporation of DNA barcodes presents a complementary approach...