Sequence-specificDNABindingbyEcoKI,aTypeIADNARestrictionEnzymeLynnM.Powell,DavidT.F.DrydenandNoreenE.Murray*InstituteofCell&MolecularB..
网络蛋白 网络释义 1. 蛋白 ...对DNA具有识别特异性,又称序列特异性DNA结 合蛋白(sequence specific DNA binding proteins) ? ◆具有多种功能,包括基 … www.docin.com|基于 1 个网页
The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by...
In this report we provide evidence that phosphorylation of serine 378 within the carboxyl-terminal negative regulatory domain of the human p53 protein by protein kinase C correlates with loss of PAb421 reactivity and a concomitant activation of sequence-specific DNA binding. These effects are reversed...
We also show that single-stranded DNA does not stimulate binding by a truncated p53 that lacks the C-terminal domain. Finally, we establish that a peptide spanning the p53 C-terminus has the ability in trans to stimulate sequence-specific DNA binding by p53 dramatically. These data taken ...
this is the first case in which a regulatory interaction between the Salm protein and one of its targets in Drosophila is shown to rely on Salm binding to a target sequence, and confirm that in this instance, the Salm protein acts as a canonical sequence-specific DNA binding protein with tr...
The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. Proc Natl Acad Sci U S A. 2005;102:6907–12. Article PubMed Central CAS PubMed Google Scholar Rastogi C, Liu D, Bussemaker H. SELEX: functions for analyzing SELEX-seq data. ...
folding. The DNA library was then incubated for 30 min with gentle agitation in a 500 lL binding reaction with 20 lL 5% bead suspension containing PBS-1 mM MgCl 2 . Beads were then washed five times with 1 mL of the same buffer using a magnetic capture stand. Bound DNA was ...
The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tight