While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its carboxyl terminus, c-Myc contains a basic-helix-loop-helix (bHLH) motif, which is important for dimerization and specific DNA binding,...
内容简介· ··· The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the...
We have investigated the sequence-specific DNA-binding properties of M.MspI under equilibrium conditions, using gel-mobility shift assays and DNasel footprinting. M.MspI binds to DNA in a sequence-specific manner either alone or in the presence of the normal methyl donor S-adenosyl-L-methionine ...
网络蛋白 网络释义 1. 蛋白 ...对DNA具有识别特异性,又称序列特异性DNA结 合蛋白(sequence specific DNA binding proteins) ? ◆具有多种功能,包括基 … www.docin.com|基于 1 个网页
MIT 分子生物学 part2 9.7 The Gal4 Domain Swapping Experiment - 哔哩哔哩 (bilibili.com) MIT 分子生物学 part2 4.6 Regulation of Bacterial Transcription - 哔哩哔哩 (bilibili.com)MIT 分子生物学 夹逼法 分享至 投诉或建议评论 赞与转发目录 6 1 0 0 0 回到旧版 顶部...
The protein–protein interaction plays an essential role in both enhancing the selectivity of specific DNA binding and increasing the sensitivity of equilibrium binding to changes in protein concentration. The chapter also presents the model systems with noncovalent dimerization domains....
B-cell-specific transcription of immunoglobulin genes is mediated by the interaction of a POU domain containing transcription factor Oct-1 or Oct-2, with the B-cell-specific coactivator OCA-B (Bob-1, OBF-1) and a prototype octamer element. We find that OCA-B binds DNA directly in the maj...
Genetic variation in the New World: ancient teeth, bone, and tissue as sources of DNA. Examination of ancient and contemporary Native American mtDNA variation via diagnostic restriction sites and the 9-bp Region V deletion suggests a single w... DA Merriwether,F Rothhammer,RE Ferrell - 《Exper...
Sequence-specific DNA-binding proteins play a key role in many fundamental biological processes, such as transcription, DNA replication and recombination. Very often, these DNA-binding proteins introduce structural changes to the target DNA-binding sites including DNA bending, twisting or untwisting and...
proteinandstaphylococcalproteinA-Cfusion.The deletionanalysisimplicatesaroleforthecarboxyl-terminalregionofthe proteininDNAbinding. 71996AcademicPressLimited *CorrespondingauthorKeywords:MuCprotein;chemicalfootprinting;momregulation Introduction Regulationofgeneexpressionisanintricately controlledprocessinvolvingtheDNAbinding ...