Survival Sepsis CampaignRefractory ShockSurvival SepsisIntroduction Sepsis is a major problem in healthcare, with high mortality. Application of surviving sepsis campaign evidence-based recommendations is a way of improving quality of care. Methods Concurrent data collection for all patients admitted to an...
Logistic regression revealed a negative association of SIC with survival (p = 0.011; Additional file 1: Table S2). Of note, there was no difference regarding the necessity of mechanical ventilation between SIC positive and SIC negative patients with sepsis. However, SIC positive patients had ...
The exclusion criteria included refusal of consent, previous therapy with carbapenem antibiotics, very low probability of survival assessed using the Simplified Acute Physiology Score II (SAPS II)24 (score ≥65 points), and severe immunosuppression (eg, AIDS or long-term corticosteroid therapy [>0.5...
of 956 patients with severe sepsis and septic shock, and found that high IgA and IgG levels on the day of diagnosis of sepsis were significantly associated with decreased 90-day survival in patients with sepsis, whereas changes in IgM levels were not significantly associated with the survival. ...
Sepsis is a life-threatening condition caused by an exaggerated reaction of the body to an infection, that leads to organ failure or even death. Since sepsis can kill a patient even in just one hour, survival prediction is an urgent priority among the me
The Kaplan–Meier (K-M) method was used to plot unadjusted survival curves, and the log-rank test was used to compare the survival curves between two groups. Subgroup analysis was also conducted to investigate whether NLR_NPR had any impact on different subgroups, including age, respiratory ...
To this end, recently published studies demonstrate the phrenological inhibition of S100A8/A9 using Paquinimod, a specific inhibitor that impedes the binding of S100A9 to TLR4 significantly ameliorates sepsis-induced hyperinflammation, in turn improving survival rate of septic mice [32, 33]. Herein,...
Sepsis is life-threatening organ dysfunction caused by dysregulated host response to infection according to the 2016 guidelines issued by the Surviving Sepsis Campaign. It is one of the leading causes of ICU admissions, which affects patients of all ages with multiple comorbidities and underlying diagn...
Conclusions The reinforcement learning model we proposed for sepsis medication treatment, has practical clinical value and can improve the survival rate of patients to a certain extent while ensuring the balance and safety of medication.This is a preview of subscription content, log in via an institu...
Kumar A, Roberts D, Wood KE et al (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34(6):1589–1596 Article PubMed Google Scholar Kuroshima T, Kawaguchi S, Okada M (2024) Current...