In adults, absence or dysfunction of the adaptive immune system has a profound impact on survival in preclinical models [205]. Genome-wide mRNA expression profiling (GWEP) during pediatric septic shock revealed widespread repression of gene pathways corresponding to the adaptive immune system [224]....
Logistic regression revealed a negative association of SIC with survival (p = 0.011; Additional file 1: Table S2). Of note, there was no difference regarding the necessity of mechanical ventilation between SIC positive and SIC negative patients with sepsis. However, SIC positive patients had ...
Sepsis is a life-threatening condition caused by an exaggerated reaction of the body to an infection, that leads to organ failure or even death. Since sepsis can kill a patient even in just one hour, survival prediction is an urgent priority among the medical community: even if laboratory tes...
Therefore, predicting the prognosis of sepsis and implementing timely and effective treatment measures are crucial for improving patient survival and clinical outcomes. In recent years, increasing evidence has suggested that inflammation and immune response play a pivotal role in the occurrence and ...
The exclusion criteria included refusal of consent, previous therapy with carbapenem antibiotics, very low probability of survival assessed using the Simplified Acute Physiology Score II (SAPS II)24 (score ≥65 points), and severe immunosuppression (eg, AIDS or long-term corticosteroid therapy [>0.5...
The Kaplan–Meier analysis was applied with regard to survival experiments, and log-rank test was used for testifying the differences between survival curves. Two tailed P-value less than 0.05 were considered to be statistically significant.
inflammation [149,150], and its inhibition may resolve the cytokine storm. A drug that inhibits the IL-1-receptor, anakinra, has an excellent safety record in humans, however, it has failed to show a survival benefit after sepsis or COVID-19 [149,150]. The ‘single-step’ drug target ...
Early identification and aggressive treatment, including fluid resuscitation, broad spectrum antibiotics, and close monitoring of perfusion, has been shown to improve survival [4-6]. Recently, the Centers for Medicare and Medicaid Services (CMS) adopted a quality process aimed at standardizing the ...
Survival SepsisIntroduction Sepsis is a major problem in healthcare, with high mortality. Application of surviving sepsis campaign evidence-based recommendations is a way of improving quality of care. Methods Concurrent data collection for all patients admitted to an ICU with the diagnosis of community...
We obtain the survival rate according to the return value (see Methods). The expected return and the survival rate on the test dataset are shown in Table 1. The results show that the AI policy has a higher survival rate than the human clinician’s policy. The feature selection process impr...