Comparison of trends in sepsis incidence and coding using administrative claims versus objective clinical data. Clin Infect Dis. 2015;60(1):88-95.Rhee C, Murphy MV, Li L, et al; Centers for Disease Control and Prevention Epicenters Program: Comparison of trends in sepsis inci- dence and ...
could ameliorate lymphopenia [166]. This hints at the necessity of considering tissue infiltration effects in lymphocyte count evaluations and proposes the potential utility of CRP and ferritin as readily accessible clinical indicators to reflect the correlation between lymphocyte levels and specific viral ...
6 Determining Clinical Criteria for Sepsis Using Existing Measures In UPMC derivation and validation data, indicators were generated for each component of the systemic inflammatory response syndrome (SIRS) criteria4; the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score8; and the ...
Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting in aggravated clinical outcomes. However, due to the substantial heterogeneity within septic patients, precise indicators in deciphering clinical trajectories and immunological alterations for septic patients remain largel...
for almost one-third of childhood sepsis cases8. The neonatal adaptive and innate immune response is also distinctly altered compared to the developing immune system of older children; it is further complicated by differences in clinical signs and biomarkers16,17,18. For diagnosis, many clinicians ...
Sepsis-induced myocardial injury (SIMI) is a severe complication of sepsis, contributing significantly to mortality. Mitochondrial dysfunction and dysregulated autophagy are implicated in SIMI pathogenesis. Long non-coding RNA MALAT1 has been associated
In 2001 [26], the diagnostic criteria for sepsis were revised. The meeting proposed a diagnostic criterion consisting of more than 20 assessment indicators of clinical symptoms and signs, that is, Sepsis 2.0. However, the complexity of this standard, coupled with a dearth of robust research foun...
Predictive models quantify the relative importance of individual clinical indicators for evaluating the risk of an adverse outcome for an individual patient [40]. These models attempt to formally test, simplify, and increase the accuracy of a clinician's diagnostic and prognostic assessment and are ...
Sepsis is a major growing global burden and a major challenge to intensive care clinicians, researchers, guideline committee members and policy makers, because of its high and increasing incidence and great pathophysiological, molecular, genetic and clinical complexity. In spite of recent progress, sho...
methods for sepsis biomarkers, especially in the multi-centered or multi-index researches. Valid evaluation needs to be performed to pick out the ideal diagnostic indicators, those both of high sensitivity and specificity in the field of data statistics and of great practical use in clinical ...