Das A, Shukla S, Rahman N, Gunzler D, Abughali N. Clinical Indicators of Late-Onset Sepsis Workup in Very Low-Birth-Weight Infants in the Neonatal Intensive Care Unit. Am J Perinatol. 2016:856-60. [PubMed: 26960700]Das A, Shukla S, Rahman N, Gunzler D, Abughali N. Clinical ...
This cohort study uses health system and research cohort data to compare the ability of existing vs new clinical criteria for sepsis to identify intensive
Exposures Sepsis was identified using clinical indicators of presumed infection and concurrent acute organ dysfunction, adapting Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria for objective and consistent EHR-based surveillance. Main Outcomes and Measures Sepsis incid...
Sepsis, as defined by Sepsis-3.0, is characterized by life-threatening organ dysfunction resulting from a dysregulated host response to infection [1,2]. Clinically, it manifests as an acute elevation in the Sequential Organ Failure Assessment (SOFA) score of ≥ 2, and timely interventions c...
However, sensitivity and specificity of blood culture varies considerably due to many factors, and the final diagnosis of neonatal sepsis is based on a combination of clinical, microbiological and haematological parameters. Aim: To find sensitive clinical indicators for suspecting neonatal sepsis and to...
In low-resource settings, alternative indicators of tissue reperfusion, such as normalization of skin temperature (37.0 °C±0.5 °C),33 capillary refill time (normal time, ≤2 s), and diminution of skin mottling,34,35 can be utilized. Patients who do not demonstrate improvement with fluid ...
Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of diagnostic tools and management strategies for SAE at the acute phase and in the long term. Early recognition and diagnosis...
SOGC guidelines note insufficient evidence for plasma exchange or plasmapheresis, noting that observational studies have suggested improved hematological and biochemical indicators, but small RCTs have found no maternal or perinatal outcome improvement. Also, an UpToDate review on “HELLP syndrome” (Sibai...
The data-mining process applied to address these issues was, as follows: (1) data selection using the MIMIC III database; (2) extraction and integration of three types of data, including multivariate features (demographic information and clinical biochemical indicators), time series data (...
Individual plasma cytokine levels are not considered good prognostic indicators in clinical practice due to the inherent variability seen in sepsis36,37, however as expected the concentrations of several cytokines were different between survivors and non-survivors. For example, IL-6 was higher in survi...