Cell NucleusColonic NeoplasmsCell DivisionAfter multiple fragmentation of neoplastic nuclei into "nucleotesimals", a recently discovered variety of amitosis, some fragments appear to be inflated to full nuclear size; others probably lyse, releasing nucleic acid, which may assist in the synthesis of ...
The staining intensity was separated into nucleus and cytoplasm in breast cancer specimens (n = 6 for para-cancerous, n = 53 for non-TNBC, and n = 9 for TNBC). Solid lines represent the median, and dashed lines represent the upper and lower quartiles. P values were ...
The cellular component gene ontology search showed de-enrichment of mitochondrial and ribosomal proteins, and enrichment of components of the nucleus and cell membrane. mRNAs that met the same inclusion criteria but had no annotated m6A sites were used as the reference category for the gene ontology...
Biomolecular Condensates in eukaryotic cells.A) Schematic of the numerous condensates in the nucleus, cytoplasm, and membranes, such as stress granule, Cajal body, P-body, nuclear speckles, et al.B) Internal structure model of condensates. For example, the stress granule is driven by liquid-liqu...
The Na NMR approach is then applied to a gel‐forming phenylalanineゞlycine (FG)ヽontaining peptide, part of the nuclear pore complex involved in controlling the traffic between cytoplasm and cell nucleus. It is shown that the Na NMR together with the O NMR provide a detailed picture of ...
or organelles with specific properties and functions to orchestrate biochemical reactions. Typically, lipid bilayer membranes separate the exterior from the interior environment of a membrane-bound organelle, such as the nucleus, endoplasmic reticulum, lysosomes, mitochondria, secretory vesicles, and Golgi ...
Both DDX3XΔIDR1 and DDX3YΔIDR1 were diffused in the nucleus, even with arsenite treatment (Figure S3C), so we hypothesized that the high nuclear RNA concentrations prevented these truncations from forming condensates, since this phenomenon has been seen with other RNA binding proteins with ...
The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the te
Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to the physicochemical features of nucleosomes is challenging. Here, we develop...
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