Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE et al (2018) Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Acta Neuro- pathol 135:445-457. https://doi.org/10.1007/s00401-017-1798-3...
如果RNA序列与参考模板的正义链的顺序完全相同,则称其为"Sense RNA";如果RNA序列与参考模板的反义链的顺序完全相同,则称其为"Antisense RNA"。在基因表达中,正义链的DNA编码信息可以被转录成反义链上的RNA。这种反义链RNA可以通过多种方式对正义链RNA进行调节,例如通过RNA干扰(RNAi)和小分子RNA调节等机制。此外,...
Here we have created novel RNA-only Drosophila models, including the first models of antisense repeat toxicity, and flies expressing extremely large repeats, within the range observed in patients. We generated flies expressing ~100 repeat sense or antisense RNA either as part of a processed poly...
Using RT-PCR, endogenous antisense RNA was detected in poly(A) RNA isolated from the larval midgut. Since Southern blots indicated a single gene locus, both the antisense RNA as well as the sense mRNA encoding subunit M40 seem to originate from the same gene. 展开 ...
antisense RNAEnterovirusCoxsackievirusWe prepared sense (S) and anti-sense (AS) 3H-labelled single-stranded RNA probes by polymerase-directed in vitro transcription of a coxsackievirus B3-derived cDNA fragment cloned in the PGEM2 plasmid vector. The probes detected, by in situ hybridization, both S...
ReseaRch highlights Nature Reviews Molecular Cell Biology | AOP, published online 8 January 2009; doi:10.1038/nrm2624 GENE ExPRESSION Common sense and antisense The common perception is that uni- directional transcription occurs from the majority of promoters to generate sense RNA and that bidirectional...
...液分别作为反义链组(antisense RNA)和正义链组(sense RNA);以上述C组和LPS组为对照,2 h后Western blotting检测上清液H… d.wanfangdata.com.cn|基于8个网页 2. 感觉 生物学专业英语词汇(S)|生物化学专业英语词汇 ... sense organ 感器sense rna感觉rnasense strand 感觉链 ... ...
Preker and colleagues used RNA interference to deplete the exonucleolytic RNA exosome in human cells, preventing the degradation of unstable low-abundance transcripts. They identified a class of short, polyadenylated unstable sense and antisense RNAs transcribed from sequences 0.5–2.5 kilobases upstream...
The powerful genetic tools of Saccharomyces cerevisiae have so far been unavailable for the study of RNA interference (RNAi). Efforts to identify key components of the RNAi machinery in this species have proved futile, and the pathway has been assumed lost in all budding yeasts....
Single-stranded RNA-seq results revealed a widespread and non-random pattern of antisense transcription covering more than two thirds of the B. anthracis genome. Our analysis revealed a variety of antisense structural patterns, suggesting multiple mechanisms of antisense transcription. The data revealed ...