Sense and antisense RNA are not toxic in Drosophila models of C9orf72 -associated ALS/FTDC9orf72DrosophilaALSFTDRepeat expansionA GGGGCC hexanucleotide repeat expansionActa Neuropathologica
Sense and antisense在分子生物学中,术语"Sense"和"Antisense"通常用于描述DNA或RNA序列相对于特定的参考序列的方向和位置。在DNA中,一个基因的正义链(也称为"Sense链")是指其5'端到3'端的顺序与该基因编码的mRNA的顺序完全相同的链。反义链(也称为"Antisense链")则是指与正义链相反的DNA链,即其5'端到3'...
A DNA sequence is called "sense" if its sequence is the same as that of a messenger RNA copy that is translated into protein.[37] The sequence on the opposite strand is called the "antisense" sequence. Both sense and antisense sequences can exist on different parts of the same strand ...
2004207Clinical Reviews in Allergy and Immunology© Copyright 2004 by Humana Press Inc.1080-0549/04/207–218/$25.00Index EntriesAntisense; adenosine; airway hyperreactivity; asthma.Sense and AntisenseTherapeutic Potential of Oligonucleotides and Interference RNAin Asthma and Allergic DisordersHoward A. Ba...
近来基因组研究揭示了真核基因可通过动物基因组双向转录,即DNA正义链转录信使BNA(sense mRNA或mRNA),DNA反义链转录反义RNA(antisense RNA)。以往认为自然的antisense RNA是没有功能的,现在逐渐认识到其在基因精确调控方面具有重要的作用。因此,功能基因antiseme BNA与sense mRNA特异结合降解靶mRNA领域的探索将成为今后研...
The article discusses studies on common sense and antisense. Included are studies on the use of RNAi to deplete the exonucleolytic RNA exosome in human cells, on the asymmetric strand-specific analysis of gene expression, on the sequencing, mapping and quantifying the density of RNA polymerase ...
The powerful genetic tools of Saccharomyces cerevisiae have so far been unavailable for the study of RNA interference (RNAi). Efforts to identify key components of the RNAi machinery in this species have proved futile, and the pathway has been assumed lost in all budding yeasts....
Antisense RNAADARsAlu repeatsRNA editingHuman transcriptomeOne type of RNA editing converts adenosine residues to inosine in double-stranded regions. Recent transcriptome analysis has revealed that numerous Alu repeats, present within introns and untranslated regions of human transcripts, are subject to ...
Murray JAH (ed) (1992) Antisense RNA and DNA. Wiley Liss, New York Google Scholar Nakajima N, Mori H, Yamazaki K, Imaseki H (1990) Molecular cloning and sequence of a complementary DNA encoding 1 -aminocyclopropane-1 -carboxylate synthase induced by tissue wounding. Plant Cell Physiol 31...
The analysis of the fractionated RNA of fibroblasts indicated that the poly(Au2013)-RNA would be localized in the cytoplasm of cells. The in situ hybridization demonstrated that the sense and antisense transcripts were localized in almost the same limited areas of brain, testis, and spleen. It ...