CoV-2 mutations.The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha(B.1.1.7)and Beta(B.1.351)variants.This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a referenee for the design of mRNA vaccines targeting SARS-CoV...
As COVID-19 continues to spread rapidly worldwide and variants continue to emerge, the development and deployment of safe and effective vaccines are urgently needed. Here, we developed an mRNA vaccine based on the trimeric receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein fus...
et al. mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant. Cell Rep. Med. 3, 100529 (2022). Article PubMed PubMed Central CAS Google Scholar Muik, A. et al. Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-...
Generally, nanoparticle (NP) vaccines can generate a more potent immune response than mRNA vaccines [2]. We and others have developed various self-assembled NP vaccines, which employ a SpyTag/SpyCatcher conjugation system to present immunogens on the surface of NPs [3, 4]. However, the ...
Groettrup. PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines. Adv. Drug Del. Rev. 57(3):475–482 (2005). doi:10.1016/j.addr.2004.09.007. CAS Google Scholar A. Luzardo-Alvarez, N. Blarer, K. Peter, J. F. Romero, C. Reymond, G. Corradin, ...
In addition, our RBD-HR/trimer vaccine showed a strong boosting effect against Omicron variants after two doses of mRNA vaccines, featuring its capacity to be used in a prime-boost regimen. In mice and non-human primates, RBD-HR/trimer vaccination could confer a complete protection against ...
mRNA-based therapy has been evaluated in preclinical and clinical studies for the treatment of a wide variety of disease such as cancer immunotherapies and infectious disease vaccines. However, it remains challenging to development safe and efficient delivery system. Here, we have designed a novel ...
2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[...
Nanomedicines suffer from poor drug loading and uncontrolled ‘burst release’ after administration. Combining prodrug strategies with nanostructured carriers can help to overcome these limitations by improving diffusion through biological barriers, enzy
This research indicates that the immunogenicity of peptide epitope vaccines can be effectively enhanced by developing self-assembled peptide-polymer hybrid nanostructures.doi:10.1007/s13346-023-01410-yKhazaei, SaeedehTranslate BioSanofi Sanofi-Aventis mRNA Ctr Excellence Sanofi Sanofi-Aventis mRNA Ctr ...